Novel resistance breaking antimalarial N-myristoyltransferase (NMT) inhibitor, binding to NMT peptide binding pocket

Novel cell-active and potent inhibitor of bacterial DNA repair, potentiating quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus

Novel Probe for NLRP3 Inflammasome Inhibitor MCC950

First in-class allosteric inhibitor of a bacterial IMPDH, showing to counteract the activation by the natural positive effector, MgATP, and to block the enzyme in its apo conformation

Novel plant immune-priming agent, acting as a partial agonist of salicylic acid

Novel plant immune-priming agent, acting as a partial agonist of salicylic acid

Mtb growth inhibitor, inhibiting Mtb GlgB activity by interacting to its active site residues

Potent inhibitor of the TGF-β type I receptor activin receptor-like kinase 5 (ALK5)

Novel ALK5 inhibitor

Janus-associated kinase (JAK) inhibitor

Novel potent and selective lysine-specific demethylase 1 (LSD1) inhibitor

Novel selective Mtb-DHFR inhibitor as an antimycobacterial agent

Novel selective inhibitor of PfHsp90, bypassing its highly similar human orthologs

Antiprion agent, reducing PrP(Sc) levels in dividing and stationary-phase cells

Selective estrogen receptor modifier (SERM), being a selective ERß agonist

Antidepressant and cerebral activator, acting as a serotonin releasing agent, norepinephrine reuptake inhibitor, and NMDA receptor antagonist, enhancing acetylcholine release via activation of the 5-HT4 receptor

Topoisomerase I (Top1) inhibitor

Platelet aggregation inhibitor acting as a reversible Cyclooxygenase>cyclooxygenase inhibitor

Metabolite of tryptophan, reducing the interleukin-8 (IL-8) response after IL-1β stimulus, interacting with the transcription factor aryl hydrocarbon receptor (AHR) and preventing transcription of the inflammatory cytokine IL-8, being anti-inflammatory in

Natural antibiotic, selectively inhibiting bacterial tryptophanyl-tRNA synthetase (TrpRS)

Novel inhibitor of dihydroorotate dehydrogenase (DHODH), promoting myeloid differentiation and inhibiting the proliferation of acute promyelocytic leukemia HL-60 cells, also suppressing cell growth in various other types of cancer cells

Topoisomerase I (Top1) inhibitor