Novel osteoclastogenesis inhibitor, preventing ovariectomy-induced osteoporosis in ddY mice

Iminosugar, binding selectively to N370S glucocerebrosidase and restoring its correct conformation and, consequently, enhancing its activity

Potent inotropic agent, inhibiting both PDE3 and PDE4

Natural essential oil, showing activity against T. muris

Natural antibacterial agent with cytotoxicity and hemolytic properties against a larger panel of Gram-negative bacteria

P2X-purinoceptor antagonist

Natural genistein derivetive with antibacterial and antifungal activities

Inhibitor of the cellulose biosynthesis, inhibiting anisotropic cell expansion resulting in a severely swollen and stunted growth phenotype

Biological Active Reagents

Novel prodrug of potent IspH inhibitor, killing clinical isolates of several multidrug-resistant bacteria, including those from the genera Acinetobacter, Pseudomonas, Klebsiella, Enterobacter, Vibrio, Shigella, Salmonella, Yersinia, Mycobacterium and Baci

Novel inhibitor of COX and neutrophil migration

Distinct IKur blocker

Unique topoisomerase inhibitor, showing significant growth-inhibitory effects against large-cell lung cancer (Lu-116) and gastric adenocarcinoma (St-4)

Novel Potent and Selective A3 Antagonist

Novel degrader of CRABP proteins

Novel highly potent (EC 50 = 1.6 nM) aryl hydrocarbon receptor (AhR) agonist with high affinity (K i = 88 nM)

Novel Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitor, showing a remarkably low toxicity both in vitro and in vivo and increasing the function of regulatory T cells (Tregs) at well-tolerated concentrations

Novel selective HDAC6 inhibitor

Novel PP2A ligand, protecting against memory impairment and focal cerebral ischemia in mice

Novel neuroprotective agent

Novel, potent, selective, and BBB-permeable P2X7 antagonist

Novel highly potent, orally bioavailable hepatitis C virus (HCV) entry inhibitor