Novel inhibitor of the plant inositol phosphorylceramide synthase ((IPCS), demonstrating herbicidal activity

Muscarinic Acetylcholine Receptor Hybrid Ligand, possessing noticeable M2/M4 mAChR selectivity

Orally bioavailable inhibitor of Hedgehog signaling, inhibiting tumor initiation and metastasis in pancreatic cancer

Natural toxic furanoterpenoid found in mold-damaged sweet potatoes

Natural inhibitor of the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor, binding Sec61α to Inhibit Protein Translocation

Novel inhibitor of glioblastoma multiforme (GBM), inhibiting cell viability of low-passage patient-derived GBM spheroids, blocking tube-formation of endothelial cells in Matrigel, showing no effect on primary hematopoietic CD34+ progenitor spheroids or as

Inhibitor of the uPAR·uPA protein-protein interaction, blocking cancer cell invasion

Irreversible and nonselective Monoamine_oxidase_inhibitor>monoamine oxidase inhibitor (MAOI)

Novel inhibitor of protein-protein interaction (PPI), targeting integrin αvβ3-osteopontin interface, blocking OC maturation from murine bone marrow-derived macrophages, as well as the resorptive function of OCs, impairing downstream signaling of integrin

Sulfasalazine analog, releasing 5-aminosalicylic acid and a nontoxic carrier molecule in the gastrointestinal tract

Novel potent inverse agonist of the chemokine receptor CXCR4, preventing CXCL12-mediated chemotaxis and triggering apoptosis in a panel of 18 cell lines and primary cultures, with superior mobilizing properties in vivo

NIR-II cyanine dye for cancer treatment and diagnosis

Novel interleukin-1 (IL-I) receptor-associated kinase (IRAK) modulator

Novel potent and selective degrader of IRAK3, inducing proteasome-dependent degradation of IRAK3 and showing both CRBN and IRAK3 binding for activity

Novel Orally Efficacious IRAK4 Inhibitor, Targeting MyD88L265P Mutant Diffuse Large B Cell Lymphoma

Novel inhibitor of CDC25 phosphatases, actively against human cancer cells

Inhibitor of IRE1 endoribonuclease activity, strongly inhibiting XBP-1 splicing in an in vivo model of acute endoplasmic reticulum stress.

ET B receptor agonist, showing anti-apoptotic activity and protecting neural cells in rats with cerebral ischemia

Novel potent hA2BAR antagonist (Ki = 3.66 nM)

Neutral BBB crossing reactivator for acetylcholinesterase inhibited by paraoxon, also acting as anticonvulsant

Selective thromboxane A2 (TXA2) synthase inhibitor

Natural Stabilizer of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface