Novel activator of Lecithin:cholesterol acyltransferase (LCAT) including some familial mutations, by forming a hydrophobic adduct with Cys31

Novel potent angiogenesis inhibitor, inhibiting VEGFR-2 and JAK/STAT3 signalling in primary cultured human endothelial cells and cancer cells

Novel clickable linker for estrogen receptor degraders

Novel potent and selective RON receptor tyrosine kinase inhibitor

Novel potent and selective covalent inhibitor of EGFR and Her2 exon20 insertion mutations, exhibiting selectivity over wild type EGFR and within the kinome

Novel potent inhibitor of the NOX2-dependent oxidative burst in neutrophils by activating the glycolytic enzyme phosphofructokinase-1 liver type (PFKL) and dampening flux through the pentose phosphate pathway

Novel potent and selective covalent inhibitor of EGFR and Her2 exon20 insertion mutations, exhibiting selectivity over wild type EGFR and within the kinome

Novel dual inhibitor of GSK-3β and aurora kinase A, increasing somatic cell plasticity and inhibiting tumorigenicity

Novel Aurora Kinase A Inhibitor

Novel Src family tyrosine kinase inhibitor with anti-inflammatory effects in response to Aß stimulation of microglia

Novel inhibitor of human lactate dehydrogenase A (LDHA)

Novel Inhibitor of SIRT1; Inhibitor of the human MDM2-p53 interaction

Novel PAK3 kinase inhibitor, inhibiting p53-​inactivated cancers

Novel inhibitor of PERK stress-dependent eIF2α phosphorylation with no toxicity to the cells

Novel TDP-43::GFP aggregation inhibitor

Necroptosis inhibitor

Novel inhibitor of phosphatidylcholine transfer protein (PC-TP)

Potent and metabolically stable inhibitor of necroptosis, a regulated caspase-independent cell death pathway

Novel cdk5/p25 kinase inhibitor

Novel potent tau kinase inhibitor, targeting CDK5​/p25 and GSK3β

Potent haspin kinase inhibitor

Novel ALK2 inhibitor