Natural carnitine derivative, playing a role in mitochondrial metabolism and demonstrating beneficial cardiovascular effects

Respiratory quinolone antibiotic, exhibiting enhanced activity against the important respiratory pathogen Streptococcus pneumoniae

Neuroprotective, anti-inflammatory, and anti-diabetic agent, protecting against DNA damage and apoptosis induced by ultraviolet light

Selective estrogen receptor modulator (SERM)

Hematologic malignancy-selective membranolytic peptide from the antimicrobial core (RRWQWR) of bovine lactoferricin

Novel potent and selective antagonist of exportin-1, attenuating dual NF-κB signaling and the Nrf2 cytoprotection pathway via targeting exportin-1 in colitis mice

Novel non-secosteroidal vitamin D receptor (VDR) ligand

Novel irreversible inhibitor of cell division cycle 25B, inhibiting human cancer cells via ROS generation

Potent and specific pan-PIM inhibitor, inhibiting proliferation of several AML cell lines, showing dual antitumoral and bone antiresorptive effects

Novel S. typhimurium infection inhibitor on the activity of DUSP3, DUSP11, and DUSP27

Novel inhibitor of cystine stone formation for treatment of cystinuria

Natural precursor of histamine; reversible inhibitor of protein synthesis

Serotonin-norepinephrine-dopamine triple reuptake inhibitor (SNDRI); Anti-depressant

Novel inhibitor of AMA1–RON2 interaction, blocking merozoite invasion from schizont-infected RBCs; Cytochrome P450 inhibitor

Inhibitor of cholinephosphotransferase (CPT), phosphatidyl-N-methylethanolamine N-methyltransferase (PME-NMT), and phosphatidyl-N,N-dimethylethanolamine N-methyltransferase (PDE-NMT)

Potent positive inotropic agent, inhibiting myocardial cell apoptosis

Novel inhibitor of the oncogenic Lin28-let-7 interaction

Natural capsid inhibitor

Novel Fused Benzodiazepine Hybrid Payload for Antibody-Drug Conjugate (ADC)

5HT-4 antagonist with moderate 5HT-3 antagonist properties

Lipid II binder, causing specific upregulation of the vancomycin-resistance associated gene vraX which is implicated in the cell wall stress stimulon that confers glycopeptide resistance

The first inhibitor of the catalytic activity of AChE and AChE-induced amyloid-beta aggregation protecting against reactive oxygen species