Novel competitive GLUK5 receptor antagonist

Prodrug of LY354740, highly selective and potent agonist of group II mGlu receptors (mGluR2)

Novel inhibitor of the type I transforming growth factor beta receptor (TβRI)

Novel F1F0-ATPase modulator, significantly decreasing M2 glutamate and increasing M4 glutamate

Nove fluorescent probe for highly sensitive monitoring drug induced lysosomal pH value changes, exhibiting good biological compatibility, low cytotoxicity and high resistance to photobleaching

Natural Potent Marine-Derived Elastase Inhibitor

Inhibitor of viral replication, especially useful in the treatment of the Herpes family of viruses which includes Herpes Simplex 1 and 2 , EBV , CMV and Varicella.

Inhibitor of cyclooxygenase (COX); Pan partial agonist of PPARγ, PPARα and PPARβ/δ

Novel inhibitor of the transcriptional activity of β-catenin, degrading the expression of β-catenin by stabilizing axin 2 and diminishing downstream proteins levels, including c-Myc and cyclin D1, effectively shrinking tumor xenograft derived from colonic

TRPC4/5 channel blocker, exhibiting antidepressant and anxiolytic effects

Novel selective muscarinic M1 receptor positive allosteric modulator, significantly improved scopolamine-induced cognitive deficits without prominent signs of diarrhea at up to 1000 mg/kg in mice

Novel selective muscarinic M1 receptor positive allosteric modulator, showed both significant improvement of scopolamine-induced cognitive deficits and severe diarrhea

M4K2209 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 9 nM, >180-fold selective over ALK5 (IC50=2427 nM).

Novel potent and selective ALK2 inhibitor, showing high initial brain uptake, including in the region of interest (pons)

Novel CNS Penetrant ALK2 Inhibitor for the Treatment of Diffuse Intrinsic Pontine Glioma

Partial antagonist of mGlu5

Novel Peptide Deformylase (PDF) Inhibitor, having inhibitory activity against HeLa, A549 and MCF-7

Novel potent and selective inhibitor of UppS without off-target effects on membrane potential

Novel inhibitor of the bacterial lipoprotein targeting chaperone, LolA

Natural immunomodulator, significantly decreasing TNF-α and IL-10 cytokine production, regulating the NF-κB and MAPK signaling pathways, displaying the strongest antiproliferative effects with IC50 values of 2.84 and 0.95 μM against A431 and HeLa cancer c

Potent and selective inhibitor of the induction of cytopathic effect by CHIKV and VEEV

Polyether ionophore antibiotic, inhibiting proliferation and induces apoptosis in myoblast cells