Cyclooxygenase 3 (COX3) inhibitor, acting as a potent inductor of cytochrome P450 isoenzymes CYP2B6 and CYP3A4

Potent, long-lasting, and selective antagonist of morphine-mediated antinociception

Natural potent anti-proliferative agent, inducing apoptotic cell death

Inhibitor of pro-inflammatory mediator release from mast cells

Useful pharmaceutical building block

Novel photosensitizer as a photodynamic antimicrobial agent against Staphylococcus aureus, Escherichia coli, Candida albicans, and Methicillin-resistant S. aureus (MRSA)

Novel inhibitor of ABCG2 transporter function

Natural antifungal agent, significantly inducing lipid peroxidation, activating the antioxidant enzymes, and exhibiting effective activity against F. solani (EC50 = 10.56 µM)

Metablite of PRIMA-1 and APR-246, covalently binding to cysteine residues in mutant p53 and wild type p53, and being increased in unfolded p53, inducing massive apoptosis in p53 null tumor cells

Novel Class of Cannabinoid CB2 Receptor Inverse Agonist

Peripherally restricted μ-opioid antagonist

Highly Selective Class II MET Inhibitor

Dopamine D2 antagonist, antiemetic

Non-depolarizing muscle relaxant

Radiographic Contrast Agent

Novel Dual Fluorescent and Magnetic Resonance False Neurotransmitter

Novel potent negative allosteric modulator (NAM) of mGlu2

Novel potent inhibitor of the p53-MDM2 interaction with an IC50 value of 67.5 nmol/L, against acute leukemia cell lines with different p53 status and was much less effective in inducing MDM2 degradation

mG2N001 is a potent negative allosteric modulator (NAM) of metabotropic glutamate receptor 2 (mGluR2) with IC50 of 93 nM.

Novel, multi-targeted kinase inhibitor, demonstrating potent inhibition of Trk, RET and DDR, in addition to Met, Axl and VEGFRs

Selective metabotropic glutamate 2/3 receptor agonist

Potent and orally active group II mGluR antagonist with antidepressant-like potential