Novel endoplasmic reticulum proteostasis modulator, enhancing insulin production in pancreatic β cells, inhibiting the UPR, alleviating ER stress and protein aggregation, improving intracellular insulin levels and insulin secretion

Novel Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake

Selective inhibitor of Myosin Light Chain Kinase (MLCK)

Novel IKK2 inhibitor, decreasing NF-κB activation and down-regulating the expression of a number of inflammatory proteins

Novel potent DNA binding agent, stabilizing topoisomerase-dependent cleavage, demonstrating exceptional efficacy against a number of murine and human tumor models

Second generation 5-LO inhibitor, blocking the production of leukotrienes

Novel selective and potent inhibitor of recombinant h12/15-LOX and cellular mouse 12/15-LOX (m12/15-LOX)

Potent and selective competitive inhibitor of human epithelial 15-lipoxygenase-2 (15-LOX-2)

Potent and selective mixed-type inhibitor of human epithelial 15-lipoxygenase-2 (15-LOX-2)

Novel potent inhibitor of EBOV infection

Novel Inhibitor of Human Cytomegalovirus

Potent inhibitor of STAT3 and Akt signaling

Novel dual JAK/Src kinase inhibitor, suppressing growth of diverse cancer cells

Novel inhibitor of human cytomegalovirus (HCMV) infection

Potent agonist of TRPML channels specifically activating lysosomal ML1 currents

Novel potent and selective MALT-1 protease inhibitor, showing improved solubility and permeability in comparison with MLT-748

Novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme

Novel potent and selective HDAC8 inhibitor

Novel potent and selective HDAC8 inhibitor

Novel potent and selective HDAC8 inhibitor

Novel highly potent and selective MMP13 inhibitor

Negative allosteric modulator (NAM) ligand for the mGlu5 receptor