Novel Mmpl3 inhibitor, indirectly blocking translocation of Trehalose Monomycolates across the IM

Highly water-soluble antifibrotic agent, reducing the profibrotic phenotype induced in vitro in primary human fibroblasts and ameliorating bleomycin-induced pulmonary fibrosis in vivo

Novel inhibitor of lanosterol-14-alpha-demethylase (TcCyp51)

The first small-molecule anti-plasmodial agent, disrupting rosetting, simultaneously restoring microcirculation and reduce parasite load

Novel antimalarial agent against asexual stages of P. falciparum

Novel potent Plasmodium lactate transporter PfFNT

Novel MEP pathway-targeting antimalarial agent

Novel antimalarial agent with increased efficacy against one or more pfatp4 mutated clones

Novel Inhibitor of Plasmodium falciparum

Novel antischistosomal agent against chronic S. mansoni infection

Novel antischistosomal agent against chronic S. mansoni infection

Novel antimalarial agent with increased efficacy against one or more pfatp4 mutated clones

Novel inhibitor of Plasmodium falciparum, killing both blood- and sexual-stage P. falciparum parasites

Novel antimalarial agent against Plasmodium falciparum

Novel antimalarial agent, targeting P. falciparum farnesyltransferase PfFT, showing remarkable growth inhibition with EC50 value of 0.4 µM and presenting good selectivity index (SI > 250)

Selective allosteric inhibitor of Plasmodium Kinesin-5

Novel potent inhibitor of P. falciparum asexual blood stages, inhibiting heme detoxification

Novel potent broad antiparasitic agent against intracellular Leishmania amastigotes, Trypanosoma brucei, and Plasmodium falciparum

First-in-class acetyl-CoA synthetase (AcAS) inhibitor, showong single digit nanomolar in vitro activity against P. falciparum and P. vivax clinical isolates, and potently blocking P. falciparum transmission to Anopheles mosquitoes

Novel anticancer agent, inducing apoptosis, inhibiting migration and invasion

Novel highly potent and selective MNK1/2 kinases inhibitor

Potent and selective Mnk2 inhibitor