Novel potent and selective antagonist of GluN2A-containing NMDA receptors

Novel highly potent and selective 5-HT2C agonist

Novel, potent inducer of apoptosis via the MAP kinase pathways. Inhibitor of several kinases including the tyrosine kinase FLT3-ITD

Novel inhibitor of the main protease (Mpro) of SARS-CoV-2

Novel positive allosteric modulator (PAM) of mas-related G protein-coupled receptor X1 (MRGPRX1), reducing behavioral heat hypersensitivity in humanized MRGPRX1 mice, demonstrating the therapeutic potential in treating neuropathic pain

Activator of MrgX1 receptor signaling

Novel peripheral CB1R antagonist, being highly biased toward inhibiting CB1R-induced β-arrestin-2 (βArr2) recruitment over G-protein activation

Novel potent and selective RORγT inhibitor, showing no appreciable activity against a panel of related nuclear hormone receptors

Novel potent RORγT inhibitor

Novel potent and selective RORγT inhibitor, showing no appreciable activity against a panel of related nuclear hormone receptors

Novel selective and reproducible inhibitor of DNA synthesis in E. coli JL553

Selective enhancer of the ATP effects at fast desensitizing P2X (P2X1 and P2X3) receptors

Potent P2Y14 receptor agonist

Selective P2Y6 agonist

Selective P2Y2 agonist

Potent P2Y6 agonist

Potent and selective P2Y6 receptor agonist

Novel highly potent human CD73 inhibitor (K i = 0.673 nM)

Novel potent antagonist of P2Y 14 receptor (P2Y 14 R) (IC 50 ~20 nM at hP2Y 14 R/mP2Y 14 R)

Novel potent P2Y14 Receptor Antagonist (IC 50 , 15 nM)

Bitopic fluorescent antagonist of the A2A adenosine receptor

Novel highly selective A1 adenosine receptor (A1AR) agonist