Inhibitor of extrinsic and intrinsic thrombin generation, inhibiting clot-bound and free (fluid-phase thrombin)

Activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4

Natural DnaE1 blocker, inducing a DNA damage response in Mycobacterium tuberculosis (Mtb) and inhibiting growth by blocking the replicative DNA polymerase, DnaE1

Potent suppressor of inducible nitric oxide synthase (iNOS; NOS II)

Novel selective NaV1.1 inhibitor, reducing visceral hypersensitivity

Novel selective blocker of NaV1.7 with little affinity for NaV 1.2, 1.3, or 1.6, being more potent at human vs guinea pig NaV1.7

Potent and selective blocker of voltage-gated Nav1.7 sodium channels

Potent NaV1.7 blocker, being 5-10 fold more potent than NaV 1.2 and NaV 1.6

Novel CXC chemokine receptor 2 (CXCR2) antagonist

Dual peroxisome proliferator-activated receptor gamma and alpha (PPARgamma and PPARalpha) agonist

Potent and selective A1 adenosine receptor antagonist

Biological Active Reagents

L-Tyrosine caged with photosensitive ortho-nitrobenzyl side chain

Novel HIV-1 entry inhibitor

Novel HIV-1 entry inhibitor

Novel CD4-mimetic HIV-1 entry inhibitor

Potent agonist of the human 5-HT2A and 5-HT2C receptors

Potent and selective 5-HT2A receptor agonist

Novel bacterial type II topoisomerase inhibitor with activity against gram-negative bacteria and in vivo efficacy

M. tuberculosis Dihydrofolate Reductase Inhibitor

Novel inhibitor of methionine aminopeptidase 2 (MetAP2)

First-in-class, potent, and selective Lactate dehydrogenase inhibitor