Novel inhibitor of lipid metabolism, disrupting tubulin polymerization,suppressing monoglycerol metabolism depleting lipids and inhibiting the growth of both lymphoma and RCC both in vitro and in vivo

The first reported BoNT/E small molecule inhibitor

Novel inhibitor of nucleoside hydrolase (NH)

Selective inhibitor of HsEg5

Potent inhibitor of endopeptidase activity of botulinum neurotoxin type A light chain (rBoNT/A-LC)

Tyrosyl-DNA phosphodiesterase (Tdp1) inhibitor

First-in-class probe of Rad6 function, inhibiting Rad6 function and Rad6-Rad18 interaction in the PCNA ubiquitination cascade

Novel B-Raf(V600E) inhibitor

Novel stimulator of neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo.

Novel inhibitor of neutral sphingomyelinase 2 (nSMase2) for the treatment of neurodegenerative diseases

Novel free radical scavenger, against light-induced photoreceptor cell damage

Potent anti-HBV agent, targeting the NTCP-APOA1-HBx-Beclin1-mediated autophagic pathway

Novel nonpeptide selective ligand for NTS2

Novel nonpeptide potent and selective partial agonist of the Neurotensin receptor type 2 (NTS2)

Novel Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43

The first NTR-responsive PROTAC, incorporating the caging group on the Von Hippel-Lindau (VHL) E3 ubiquitin ligase ligand, efficiently degrading the EGFR protein and subsequently exert antitumor efficacy

Novel potent STAT3 inhibitor, exhibiting much improved in vivo pharmacokinetic parameters in rats and efficacies against proliferations in multiple cancer cell lines

Novel potent STAT3 inhibitor

Novel potent and selective non-thiazolidinedione partial Peroxisome_proliferator-activated_receptor>PPARγ agonist, acting as an antibiotic effectively against bacterial persisters

Novel potent CDK2 inhibitor

Novel DNA methytransferase inhibitor, be significantly safer and more effective than decitabine in xenograft models of human leukemia and colon cancer

Novel highly potent and selective MEK4 inhibitor