Pseudomonas aeruginosa autoinducer

Novel partial agonist of peroxisome proliferator-activated receptor-γ (PPARγ), recruiting PPARγ-coactivator-1α, preventing triglyceride accumulation, and potentiating insulin signaling in vitro

Photoswitchable epithelial sodium channel (ENaC) blocker

Novel glutathione-S-transferase-p-activated nitric oxide donor, inhibiting proliferation and inducing apoptosis by targeting PI3K/AKT/mTOR and MEK/ERK pathways in hepatocellular carcinoma cells

Novel potent and selective inhibitor of protein arginine deiminase 3 (PAD3), having 15600 kinact/KI values and ≥10-fold selectivity for PAD3 over PADs 1, 2, and 4.

Partial DAT/5-HT transporter substrate

Full DAT/5-HT transporter substrate

Novel selective LYPLAL1 activator, increasing LYPLAL1’s catalytic activity likely by enhancing the efficiency of the catalytic triad charge-relay system, confering beneficial effects in a mouse model of diet-induced obesity

Full DAT/5-HT transporter substrate; Non-neurotoxic releasing agent of serotonin, norepinephrine, and dopamine; Full agonist at 5-HT2B and partial agonist at 5-HT2C

Potent dual dopamine-serotonin (DA/5-HT) releaser

Selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6

Novel Ras-Signaling Modulator, targeting acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells

Potent serotonin-3 (5-HT3) receptor antagonist

Novel TLR2 agonist as potential adjuvant for cancer vaccines

Inhibitor of the Cell_cycle>cell cycle from G0/G1 to S phase with powerful antiparasite activity

Biological Active Reagents

Tamoxifen analogue; antiestrogenic

Novel potent pan-Raf and receptor tyrosine kinase inhibitor, potently inhibits all subtypes of Rafs with IC50 values of 3.49 (BRafV600E), 8.86 (ARaf), 5.78 (BRafWT), and 1.65 nM (CRaf), respectively

Potent and highly selective small molecule inhibitor of thioredoxin reductase (TrxR)

Pathway Preferential Estrogen, activating the extranuclear signaling pathway without activity on the nuclear signaling pathway

Blebbistatin derivative, increasing water solubility, decreases the inherent fluorescence, stabilizing the molecule to circumvent its degradation by prolonged blue light exposure, and decreasing its phototoxicity while retaining the in vitro and in vivo a

Isomer of CID-5951923