Potent inhibitor of microtubule polymerization

Potent inhibitor of microtubule polymerization

Novel inhibitor of Loxosceles sphingomyelinases D (SMases D)

Novel inhibitor of Loxosceles sphingomyelinases D (SMases D)

Fluorogenic fluorescent probe for imaging lipid droplets; suitable for use with two-photon microscopy

Novel Allosteric Inhibitor of p97

Novel enhancer of the clearance of mutant aggregate-prone proteins by autophagy in mammalian cell models of Huntington's and Parkinson's disease, independent of rapamycin

Novel strathclyde minor groove binder (S-MGB), curing animal African trypanosomiasis (AAT)

Novel enhancer of the cyclin-dependent kinase (CDK) inhibitor p27(Kip)

Novel TLR2 agonist, promoting cross-presentation by mouse and human antigen presenting cells

Novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor

Selective, direct-acting covalent inhibitor of the K-Ras G12C mutant relative to wild-type Ras

Novel Active Site Inhibitor of Oncogenic K-Ras G12C

Novel Stablizer of Survival of Motor Neuron 2 (SMN2) , Post-Translationally Stablizing SMN Protein for the Treatment of Spinal Muscular Atrophy (SMA)

Novel specific splicing enhancer, targeting RNA for a specific splicing correction, recognizing the interface between U1 snRNP and the SMN2 E7 5ʹ SS, promoting the U1-C zinc finger RNA duplex binding activity

Second-generation modulator of utrophin, increasing utrophin expression in skeletal, respiratory and cardiac muscles

Novel dual inhibitor of thrombolysis and soluble epoxide hydrolase

Novel Smurf1 inhibitor, promoting bone formation in mouse models of distinctive age-related osteoporosis

Novel potent TLR1/2 Specific Agonist, Suppressing Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes

Selective ligand of GC-rich sequences in DNA

Novel potent DNA-binding topoisomerase II-directed antitumor agent.

Novel specific inhibitor of Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188)