Novel Potent Dual AChE/GSK-3 Inhibitor for the Treatment of Alzheimers Disease

Novel potent p53-MDM2/X antagonist, inhibiting MDM2 potently with a Ki value of 58 nmol/L, inducing accumulation of p53, p21 and MDM2, inhibiting cell cycle progression of U-2 OS cells at G1 phase in a p53-dependent manner

Novel inhibitor of the Klebsiella pneumoniae VapBC toxin-antitoxin (TA) system, acting as antimicrobial agents by disrupting the VapBC complex and activating VapC

Novel AMPA receptor potentiator with little agonistic effect, producing antidepressant-like effect without causing psychotomimetic effects

Long-lasting ergosterol biosynthesis inhibitor

Potent FAAH Inhibitor

Novel anti-HIV CCR5 antagonist

Novel selective 5-hydroxytryptamine type 2C (5-HT2C) receptor agonist

Novel inhibitor of the epigenetic modulator lysine-specific demethylase 1A (LSD1)

Natural ferroptosis inducer, killing colorectal cancer cells in vitro and in vivo

CYP26 inhibitor, potentiating the effects of all-trans retinoic acid on cultured human epidermal keratinocytes

Natural neurotrophic agent, promoting neurite outgrowth from neurons through PI3K/Akt pathway

Novel Antibody-Drug Conjugate PBD Dimer Payload

Superagonist at the human thyrotropin-releasing hormone receptor, reversing opioid-induced respiratory depression in isoflurane anesthetized rats

Novel Fluorescent dATP for DNA Synthesis In Vivo, exhibited high brightness, low toxicity, and rapid incorporation and depletion kinetics in both a vertebrate (zebrafish) and a nematode (Caenorhabditis elegans)

Potent and selective non-peptide δ1 opioid receptor agonist

Novel angiogenesis stimulator, promoting multiple key steps of angiogenesis parially via Akt and MAPK signalling pathways, showing anti-ischemic and anti-atherosclerosis activities, also acting as a putative PPARγ agonist

Novel potent Na V -targeting peptide, exhibiting significant increased potency for Na V 1.1, Na V 1.2, Na V 1.3, Na V 1.6 and Na V 1.7 involved in several neurological disorders including acute and chronic pain, motor neuron disease and epilepsy

Novel potent Na V -targeting peptide, exhibiting significant increased potency for Na V 1.1, Na V 1.2, Na V 1.3, Na V 1.6 and Na V 1.7 involved in several neurological disorders including acute and chronic pain, motor neuron disease and epilepsy

ADAM-17 (TACE) and MMP inhibitor, sensitizing cancer stem cells to the lethal effects of 5-FU and blocking shedding of TNF-α from cell membranes

Potent P-glycoprotein (P-gp) inhibitor

Novel selective norepinephrine reuptake inhibitor, displaying significant norepinephrine transporter (NET) inhibitory activity toward the serotonin or dopamine transporters