Tubulin-binding dolastatin-15 analog, demostrating a wide spectrum of In Vivo antitumor activity

Potent and orally active V 1B receptor antagonist with antidepressant and anxiolytic activities in rodents

Potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM)

Novel potent, selective, and orally active CRTH2 antagonist

Trans-activator of transcription (TAT) peptide, increasing Hepta-histidine (7H) permeability into cells for treatment of iPS cell-derived neurons carrying Tau or APP mutations suppressed Tau phosphorylation

Novel brain penetrant Cx43 hemichannel blocker

Potential neuroprotective agent, showing effects on cellular models of oxidative stress and neuroinflammation

Selective mast-cell-stabilizing agent, inhibiting ozone-induced airway hyperresponsiveness

Novel antagonist of IL-6 signaling

Novel antibiotic against Mycobacterium tuberculosis (Mtb), potently killing replicating, virulent Mtb H37Rv in a clavulanate-dependent manner

Novel potent MCT1 inhibitor, exhibiting good single agent anticancer efficacy properties

Highly potent activator of Nrf2; Potent phase 2 cytoprotective pathway inducer and liver carcinogenesis blocker

Novel TBK1/IKKε inhibitor

Novel anti-angiogenesis and vascular disrupting agent, exhibiting moderate inhibitory cell proliferation activity

Novel anti-angiogenesis and vascular disrupting agent, exhibiting moderate inhibitory cell proliferation activity

Novel agonist for nicotinic acetylcholine receptors (nAChRs), modestly selectively targeting α6β2 subtype

Novel potent and selective ligand of Brd2(2)

Aquaporin 1 (AQP1) channel blocker

Potent CB1 receptor inverse agonist

Novel orally bioavailableγ-secretase modulator, reducing Aβ42 levels

Potent formyl peptide receptor 2 (FPR2) agonist

Potent and selective antagonist of adenosine A2A receptors