Novel Androgen Receptor Antagonist, inhibiting the LNCaP cell line as well as cell lines with wild-type androgen receptor

Competitive S1P1/3 antagonist, increasing capillary permeability as measured by Evans blue dye leakage in mouse lung tissue

Corrector of F508del-cystic fibrosis transmembrane conductance regulator (CFTR) mutant

Inhibitor of the catalytic activity of VRV-PL-VIIIa, strongly inhibiting the hemolysis of red blood cells and VRV-PL-VIIIa-induced myotoxicity and lung hemorrhage in mice

Novel Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)

Novel inhibitor of geranylgeranyl diphosphate synthase (GGDPS)

Novel Promoter of Neuronal Branching Via Transcellular Activation of the Focal Adhesion Kinase (FAK) and the ERK1/2 Signaling Pathway In Vitro

Sphingosine kinase (SphK) inhibitor, having modest SphK2-selectivity

Novel selective agonist of TLR8

Novel non-MPEP site metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs)

Selective modulator of G protein-coupled inward rectifier K (GIRK)

Allosteric modulator of the M1 muscarinic receptor

Novel Positive Allosteric Modulator (PAM) of the Metabotropic Glutamate Receptor 5 (mGlu5)

Novel Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5, Revealing Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity

Potent and specific PAM for the rat mGluR5 receptor

Potent noncompetitive antagonist of Metabotropic_glutamate_receptor_5>metabotropic glutamate receptor 5 (mGlu5)

VU0366248 is a mGlu5 negative allosteric modulator.

Novel Positive Allosteric Modulator (PAM) of the Metabotropic Glutamate Receptor 5 (mGlu5)

Highly potent non-MPEP site metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (PAM)

Muscarinic antagonist; inhibiting ACh-induced Ca(2+) responses at rat M(1-5) receptor subtypes

Novel positive allosteric modulator (PAM) of mGlu4

Allosteric modulator of the M2/5 muscarinic acetylcholine receptor