Highly M1-selective antagonist

Novel M4 muscarinic acetylcholine receptor modulator

Novel mGlu4 positive allosteric modulator (PAM)

Novel negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety

Highly selective muscarinic M1 PAM

Selective orthosteric M1 antagonist

Novel, CNS Penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) Positive Allosteric Modulator (PAM)

Novel potent and selective metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (PAM)

Potent and selective mGlu5 negative allosteric modulator (NAM)

Novel potent mGlu4 PAM with an attractive DMPK profile, and robust efficacy in preclinical Parkinsons disease model, haloperidol-induced catalepsy (HIC)

mGlu1 positive allosteric modulator (PAM)

Novel cyclooxygenase-1 (COX-1)-selective inhibitor

Novel modulator of mammalian inward rectifying potassium (Kir) channels

Novel selective negative allosteric modulator (NAM) of metabotropic glutamate receptor subtype 2

Novel potent and highly selective mGlu1 PAM (22nM), reducing striatal DA release in vivo and displaying antipsychotic efficacy

Novel Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM)

Novel Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM)

Novel M4 positive allosteric modulator (PAM)

Novel CNS penetrant pan-muscarinic antagonist

Novel PAM of Group III (mGlu4/6/7/8) mGlu receptors

Novel selective mGlu3 NAM, showing efficacy in tail suspension, elevating zero maze and marble burying, suggesting selective inhibition of mGlu3 affords anxiolytic-like and antidepressant-like phenotypes in mice

First-in-class selective mGlu7 positive allosteric modulator (PAM), displaying CNS penetration in both mice (Kp = 2.74) and rats (Kp= 4.78)