Novel potent SphK2-selective inhibitor (Ki = 89 nM, 73-fold SphK2-selective) with validated in vivo activity

Novel SphK2-selective inhibitor with improved half-life to 8 h in mice

Novel selective SphK1 inhibitor

Novel SphK2-selective inhibitor

Novel efflux pump inhibitor (EPI)

Novel efflux pump inhibitor (EPI)

Potent, orally-active agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and growth hormone secretagogue

Novel Potent, Cell-Permeable, Conformationally Constrained Second Mitochondria Derived Activator of Caspase (Smac) Mimetic

Non-peptidic Smac mimetic, binding to XIAP, cIAP-1 and cIAP-2 proteins with higher affinities in cell growth inhibition in the MDA-MB-231 cell line

Novel potent and selective inhibitor of galactokinase (GALK1)

Novel inhibitor of IL-1

Proapoptotic and anti-inflammatory agent, inducing apoptosis by inhibiting apoptosis proteins (IAPs)

Novel activator of PP1, inducing HIV-1 transcription, reactivation of latent HIV-1 in chronically infected cells, and CDK9 phosphorylation

Potent inhibitor of microtubule polymerization

Potent inhibitor of microtubule polymerization

Novel inhibitor of Loxosceles sphingomyelinases D (SMases D)

Novel inhibitor of Loxosceles sphingomyelinases D (SMases D)

Fluorogenic fluorescent probe for imaging lipid droplets; suitable for use with two-photon microscopy

Novel Allosteric Inhibitor of p97

Novel enhancer of the clearance of mutant aggregate-prone proteins by autophagy in mammalian cell models of Huntington's and Parkinson's disease, independent of rapamycin

Novel strathclyde minor groove binder (S-MGB), curing animal African trypanosomiasis (AAT)

Novel enhancer of the cyclin-dependent kinase (CDK) inhibitor p27(Kip)