Novel inhibitor of STAT3, targeting SH2 domain

Novel potent and selective inhibitor of STAT3

Novel inhibitor targeting the DNA-binding domain of STAT3, suppressing tumor growth, metastasis and STAT3 target gene expression in vivo

Novel inhibitor of signal transducer and activator of transcription 3 (STAT3), inhibiting the proliferation of tumor cells harboring abnormal activation of STAT3, such as, MDA-MB-468, MDA-MB-231 and DU145

Novel cell-permeable selective STAT5a inhibitor prodrug, inhibiting tyrosine phosphorylation of STAT5a with selectivity over STAT5b in cultured human leukemia cells, and representing a valuable tool to define the non-redundant molecular functions of the t

Highly Potent and Selective Inhibitor of the Transcription Factor STAT5b

Novel human stem/progenitor cells proliferation activator, promoting survival and preserving stemness in human embryonic stem cells

Natural inducer of G1 arrest in primary human esophageal epithelial cells but G2 arrest in immortalized cells

Novel inhibitor of expression from canonical CREB response element-containing promoters

Novel RBP4 antagonist for treatment of Stargardt disease

Natural anti-feline infectious peritonitis virus (FIPV) agent, specifically targeting the 3CLpro of FIPV and inhibiting its replication

Novel non-nucleotide STING agonist, demonstrating antitumor activity when dosed intratumorally in a syngeneic mouse model

Novel covalent antagonist of hsSTING

Novel Fatty Acid Binding Protein 5 (FABP5) Inhibitor

Novel Fatty Acid Binding Protein 5 (FABP5) Inhibitor

Dual inhibitor of topoisomerase 1 and 2, inducing G(2) arrest in the absence of DNA damage. Inhibitor of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay

Novel inhibitor of the heterogeneous ribonuclear protein A18 (hnRNP A18)

Novel blocker of IL-17A binding to the IL-17A receptor (IL-17RA)

Novel activator of cellular ATG4B activity

Potent natural modulator of human Toll-like receptor 7 (TLR7)

Metablite of the Streptomyces antibiotics streptothricin and streptolin

Antibiotic, being used as an antineoplastic agent and to induce diabetes in experimental animals