The first nonpeptidyl, selective activator of the tissue-protective EPOR/CD131 receptor

Novel agonist of the tissue-protective erythropoietin (EPO) receptor, increasing FXN expression and EPOR phosphorylation

Inhibitor of 17β-hydroxysteroid dehydrogenases (17β-HSDs)

Novel Nonsteroidal Inhibitor of Carbonic Anhydrase IX

Novel dual Inhibitor of repair enzymes 8-oxoguanine DNA glycosylase (OGG1) and human MutT Homolog 1 (NUDT1 or MTH1), increasing sensitivity of tumor cells to oxidative stress

Novel potent c-MET inhibitor

Potent c-MET inhibitor

Sunitinib analog, acting as a potential inhibitor for nucleoside diphosphate kinase (NDK) from Leishmania major (LmNDK)

Agonist of TRPV1

Novel potent and selective inhibitor of the cellular PDGF receptor kinase and PDGF receptor-induced cell proliferation

Natural immunosuppressive agent, effectively blocking T cell proliferation and survival while profoundly inhibiting pro-inflammatory IFNγ and IL-17 production by fully differentiated effector Th1 and Th17 cells, also acting as an estrogen receptor antagon

Fluorescent substrate which can be hydrolyzed by the proteasome to release free AMC and the fluorescence of which is proportional to the proteasome activity

Novel antagonist of G-protein-coupled receptor SUCNR1 (succinate receptor 1 or GPR91)

Novel potent inhibitor of osteoclastogenesis, suppressing both equilibrative nucleoside transporters and concentrative nucleoside transporters

Novel inhibitor of airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease (COPD)

Antibacterial, inhibiting bacterial folic acid synthesis by competing with para amino benzoic acid

β-Lactam antibiotic against multi-drug resistant pathogens

Novel inhibitor of RhoG-hepcidin uptake

Neuroprotective agent, alleviating stroke-induced neuroinflammation

Peripheral vasodilator

Novel, potent, selective, and competitive antagonist of LTD4 and LTE4

D2 selective dopamine agonist, showing anxiolytic and anti-parkinsonian activities