Novel degrader of E. coli DHFR (eDHFR), as well as eDHFR-EGFP fusion proteins, demonstrating that degradation does not require covalent attachment of the tag to the target protein

Novel caged protein labeling agent

Allosteric agonist and positive allosteric modulator (PAM) of 5-HT3 receptor

Novel activator of necrostatin-1 sensitive necroptotic cell death, triggering apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia

Novel potent inhibitor of TNF-α

Novel inhibitor of tumor necrosis factor-α (TNF-α)

Emivirine analog with improved activity against drug-resistant HIV mutants

Novel non-nucleoside reverse transcriptase inhibitor of HIV-1

Novel selective inhibitor of TNKS-USP25 interaction, effectively reducing prostate cancer cell proliferation and tumor growth

Novel highly potent and selective TNKS2 inhibitor with antiproliferative effects in a colorectal cancer cell line (DLD-1) where the Wnt pathway is constitutively activated

Highly potent and selective tankyrase inhibitor

Novel potent and selective tankyrase (TNKS) inhibitor

Unique multitargeting drug conjugate with extremely low propensity for development of resistance, targeting RNA polymerase, DNA gyrase, and DNA topoisomerase IV

Novel Human Toll-like Receptor 8-Selective Agonist

Stimulator of metabolism, preventing diseases associated with parturition and peri-partum period, developmental and nutritional disorders in young animals, and bone growth disorders and tetany or paresis caused by calcium, magnesium, and phosphorus metabo

Natural agonist of TPRC1/4/5 channels, also acting as a dual PKCα and PKCθ activator, inducing an insulin resistant phenotype by inhibiting IRS1 and the PI3K/Akt pathway, activating the heat shock factor 1 (HSF1) transcription factor driving glucose depen

Novel dual TOP1 and TDP1 inhibitor, inducing both cellular TOP1cc, TDP1cc formation and DNA damage, resulting in cancer cell apoptosis at a sub-micromolar concentration

Novel narrow spectrum kinase inhibitor, potently inhibiting P38a, Src, and Syk kinase activities

Novel Selective Inhibitor of Endoplasmic Reticulum α-Glucosidase II, Exhibiting Antiflaviviral Activity

Novel highly specific fluorescent TOPK inhibitor

Nucleic acid stain, acting on viable, early apoptotic and necrotic cells differentially, showing specific staining of nuclei without any staining of the cytoplasm

Natural psychoactive agent