Natural specific inhibitor of γ-secretase, decreasing amyloid-beta levels without influencing cleavage of Notch, showing strong growth inhibitory effects on cancer cell lines and significant anti-complement activity, also acting as a PTP1B inhibitor

Metabolite of Resveratrol

Metabolite of Resveratrol

Novel Highly Selective β2-Adrenoceptor Agonist as an Oral Antiasthmatic Agent

Inhibitor of histone deacetylases

Novel TGR5 agonist, reducing glycemic and dyslipidemic cardiovascular risk in animal models of diabesity

Central sugar signal in plants, regulating sucrose use and allocation, underpinning crop growth and development

Potent and long-acting derivative of the hormone Trenbolone

EC 3.1.1.7 (Acetylcholinesterase) inhibitor, acting as an insecticide, an acaricide, an agrochemical, and a nematicide

AKT Inhibitor, Enhancing Gemcitabine Activity in Pancreatic Cancer Cells

Potent NAE-hydrolyzing acid amidase (NAAA) inhibitor

Metabolite of Trifluoperazine; Antidepressant and antipsychotic

Novel Bromodomain Binding Mimic of Lysine Acetylation

Metabolite of nicotinamide; Specific and potent inhibitor of NNMT, increasing histone methylation at H3K4 and methylated H3K4 occupancy at gene promoters

Antipsychotic and sedative agent as a potent antagonist of H1, 5-HT2A, and alpha1-adrenergic receptors

Specific inhibitor of the histone H3 lysine 9 demethylase KDM4 in HeLa cells.

Copper ion chelator, causing the triple response phenotype by affecting copper ion transport in ethylene signaling from ATX1 to RAN1

Novel anti-secretory and antiulcer agent for treatment of peptic ulcer disease and hypersecretory disorders

First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitor that Overcome Clinically Acquired Resistance

Novel opioid ligand for treatment of overactive bladder, acting as a μ-opioid receptor partial agonist

Novel potent and selective inhibitor of Tropomyosin-related kinase A (TrkA)

First-in-class highly potent and selective inhibitor of TrmD (bacterial t-RNA-(N1G37) methyltransferase)