LpxC substrate-analog inhibitor

Novel inhibitor of tubulin polymerization and caused HepG2 cells arrest in G2/M phase

Novel potent tubulin polymerization inhibitor, forming stable interactions in the colchicine-binding site of tubulin, showing significant antiproliferative activities on a panel of tumor cell lines

Novel allosteric modulator of free fatty acid receptor 3 (FFA3, previously GPR41)

Novel allosteric modulator of free fatty acid receptor 3 (FFA3, previously GPR41)

Long-acting beta2-adrenergic receptor agonist

Novel Inhibitor of Metastatic Cancer Cell Migration and Invasion

Antibiotic, inhibiting the first step in the N-linked glycosylation in eukaryotes and inducing ER stress to activate the unfolded protein response (UPR)

Inhibitor of bacterial biofilm formation in Staphylococcus epidermidis

Natural potent porcine pancreatic elastase (PPE) inhibitor

Novel anticancer agent, affecting steroid biosynthesis, increasing RagD expression, and causing abnormal cellular cholesterol localization

Novel disruptor of the bacterial protein, FtsZ

Chymase inhibitor, preventing the development and progression of non-alcoholic steatohepatitis, improving vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats

Novel highly potent and selective TYK2 JH2 inhibitor, providing robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model

First-in-class selective PRMT5 inhibitor, blocking EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected

Stable analog of phosphotyrosine (pTyr)

Novel competitive inhibitor of tyrosinase enzyme

Potent and selective dopamine D4 receptor antagonist

Novel potent inhibitor of microtubule polymerization, binding directly to tubulin α/β heterodimers via the colchicine-binding site, perturbing mitotic spindles, delaying cells in mitosis and promotes apoptosis

Novel potent and broad-spectrum antiviral agent against multiple strains of EV-D68, EV-A71, and CVB3, targeting the viral protein 2C

Selective modulator of NMDA_receptor>NMDA receptors, potentiates responses at GluN1/GluN2A

Novel pan-inhibitor of GluN1/GluN2 receptors