Novel pan potentiator of GluN1/GluN2 receptors

Novel NMDAR positive allosteric modulator (PAM), robustly potentiating responses at all GluN1/GluN2 subtypes and at neuronal NMDARs

Novel Antagonist of the USP5 Zinc Finger Ubiquitin-Binding Domain (USP5 ZnF-UBD)

Modulator of cyclic AMP generation, amplifing induced cyclic AMP formation in rat brain tissue; Nootropic

Potent ligand of synaptic vesicle protein 2A (SV2A)

Novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins

Novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins

Novel allosteric modulator of neonatal Fc receptor (FcRn), binding to the extracellular domain of FcRn

Selective competitive inhibitor of ATX-mediated hydrolysis of the lysophospholipase substrate FS-3

Selective competitive inhibitor of ATX-mediated hydrolysis of the lysophospholipase substrate FS-3

Competitive dual inhibitor of the hydrolysis FS-3 and the phosphodiesterase substrate p-nitrophenyl thymidine 5'-monophosphate

Novel non-competitive UCK2 inhibitor, suppressing nucleoside salvage in cells both in the presence and absence of DHODH inhibitors

Novel non-competitive UCK2 inhibitor, suppressing nucleoside salvage in cells both in the presence and absence of DHODH inhibitors

Novel non-competitive UCK2 inhibitor, suppressing nucleoside salvage in cells both in the presence and absence of DHODH inhibitors

Histamine H3 Receptor Antagonist in Treatments of Cognition Disorders

The first potent nonimidazole H3 receptor antagonist (pKi=8.40)

Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1), Showing Efficacy in Neuropathic Pain Amelioration

Novel potent isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor, improving survival in Ras-driven acute myeloid leukemia

Dual inhibitor of fatty acid amide hydrolase (FAAH) and α/β hydrolase domain 6 (ABHD6)

Stereoisomer of UCN-01, inhibiting protein kinase C with a slightly reduced potency than UCN-01

Novel dual inhibitor of dihydrofolate reductase (DHFR) and its functional analog, Rv2671

Fluorescent excitatory amino acid transporter subtype 1 (EAAT1) selective inhibitor