Potent and selective 11ß-HSD1 inhibitor, improving memory, including after intracerebroventricular drug administration to the central nervous system alone

Novel selective delta-opioid receptor agonist

Novel Nicotinic Acetylcholine Receptor Antagonist, Inhibiting Nicotine Reward and Decreases Anxiety and Decreasing Ethanol Intake in Alcohol-Preferring Rats

Novel inhibitor of UGM, impeding C. glutamicum growth

Novel inhibitor of UGM, impeding C. glutamicum growth

Novel potent human immunodeficiency virus type 1 (HIV-1) protease inhibito

Selective NEP inhibitor for treatment of the symptoms of Female sexual arousal disorder (FSAD)

Selective NEP inhibitor for treatment of the symptoms of Female sexual arousal disorder (FSAD)

Potent VMAT2 inhibitor

Novel chemically stable fluorescent marker of the ureter

Novel Vaccine Adjuvant for Mycobacterium tuberculosis

Novel potent and selective dual PLK1 and BRD4 inhibitor, inducing apoptosis in pediatric tumor cell lines, leading to significant tumor regression

Novel, Potent, and Selective CBP/P300 Inhibitor

Novel Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitor

Novel anti-virulence agent, rescuing nematodes from a Staphylococcus aureus infection and preventing the formation of biofilm in a dose-dependent manner without interfering with bacterial viability

Novel fluorescent UnaG ligand, binding UnaG with high affinity (Kd = 3 nM) to induce a 2.5-fold fluorescence intensity enhancement and a 10 nm red shift

Novel nonhematotoxic DNA intercalating agent with potent antitumor activity, inducing apoptosis via inhibition of key proteins in the PI3K/Akt/mTOR signaling pathway

UNC0737 is a negative control of UNC0638 and the N-methyl analog of UNC0638. UNC0737 was designed to eliminate the hydrogen bond interaction seen in the G9a-UNC0224 cocrystal structure between Asp1083 of G9a and the secondary amino group at the 4-position of UNC0224's quinazoline ring3. UNC0737 was >300-fold less potent than UNC0638 in G9a and GLP biochemical assays. As expected, UNC0737 was a poor inhibitor of G9a (IC50 = 5,000 ± 200 nM (n = 2)) and GLP (IC50 > 10,000 nM (n = 2)) in the SAHH-coupled assays.

Biotinylated UNC0638, enabling chemiprecipitation of G9a from whole cell lysates

Novel MYC protein stablizer, increasing the abundance of endogenous MYC proteintargeting the receptor tyrosine kinases KIT and platelet-derived growth factor receptor α (PDGFRα)

Novel inhibitor of ROP18, inhibiting ROP18 within cells, and abrogating its effects on the host IRG pathway

Novel Peptide Inhibitor for Calcium and Integrin Binding Protein 1 (CIB1)