Cat. No. | Product name | CAS No. |
DC66592 |
GW274150 dihydrochloride
Featured
GW274150 (dihydrochloride) is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 (dihydrochloride) displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 (dihydrochloride) exerts a protective role in an acute model of lung injury inflammation. |
438542-17-7 |
DC66593 | HP-NH2 Featured | 129132-89-4 |
DC66594 |
AJ-76
Featured
AJ-76 ((+)-AJ 76; (1S,2R)-AJ 76) is a dopamine autoreceptor antagonist. AJ-76 can increase the synthesis and turnover of dopamine in the rat brain, while having little effect on the synthesis and turnover of serotonin (5-HT) and norepinephrine. AJ-76 can also antagonize the sedative effects of low-dose apomorphine and has a weak antagonistic effect on postsynaptic dopamine receptor. |
85379-09-5 |
DC66595 |
(+)-UH 232
Featured
(+)-UH 232 is a partially selective agonist of the D3 receptor with an intrinsic activity of 0.2-0.4. (+)-UH 232 antagonized quinpirole-induced mitogenesis with a Ki value of 9.4 nM. |
95999-12-5 |
DC66596 |
Bartsiosid
Featured
Bartsioside is an anti-inflammatory agent which can be extracted from C. deserticola. Bartsioside exerts no significant cytotoxicity under 40 μM to BV-2 cells. |
62133-72-6 |
DC66597 | 1-O-palmityl-D-glucuronic acid Featured | 17460-02-5 |
DC66598 | Octadecyl β-D-glucopyranosiduronic acid Featured | 1413439-62-9 |
DC66599 | β-D-Glucopyranosiduronic acid, tetradecyl Featured | 691869-80-4 |
DC66600 |
BLU-222
Featured
BLU-222 is an investigational, oral, potent, and selective CDK2 inhibitor. BLU-222 has shown robust anti-tumor activity in preclinical models of CCNE-aberrant ovarian, breast and gastric cancer. |
2888704-84-3 |
DC66601 | Zoniporide Featured | 241800-98-6 |
DC66602 |
Gepotidacin mesylate
Featured
Gepotidacin, also known as GSK-2140944, is a potent Type II DNA topoisomerase inhibitor. Gepotidacin is a novel antibacterial drug candidate. Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats. Gepotidacin is efficacious in a nonhuman primate model of pneumonic plague. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, gepotidacin inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively. |
1624306-20-2 |
DC66603 | IWY357 Featured | |
DC66604 | EOS-984 Featured | |
DC66605 | NDI-101150 Featured | |
DC66606 |
TYRA-300
Featured
TYRA-300 is the first oral selective FGFR3 inhibitor with IC50 of 11 nM in Ba/F3 cells, and shows selectivity over FGFR1, FGFR2 and FGFR4 in Ba/F3 cells was 25-, 14-, and 36-fold, respectively. TYRA-300 demonstrates equivalent potency for FGFR3 WT and V555M/L gatekeeper mutations in enzymatic assays and in engineered RT112/84 and UM-UC-14 bladder cancer cell lines containing the V555M mutation. |
|
DC66607 | BAY2925976 Featured | |
DC66608 | BMS-986397 Featured | |
DC66609 | PLX-4545 Featured | |
DC66610 | Castadifan Featured | |
DC66611 | PF-07328948 Featured | 2936625-34-0 |
DC66612 |
VVD-130037
Featured
VVD-130037 is an oral covalent activator of KEAP/NRF2 degrader. |
3034880-93-5 |
DC66613 |
BMS-986308
Featured
BMS-986308 is a selective and orally active renal outer medullary potassium (ROMK) channel inhibitor. BMS-986308 is selective for ROMK over hERG. BMS-986308 can be used for heart failure research. |
2254333-97-4 |