Cat. No. | Product name | CAS No. |
DC47143 |
Thalidomide-5-methyl
Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. |
40313-92-6 |
DC47167 |
Thalidomide-Piperazine-PEG2-NH2 diTFA
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
|
DC47171 |
ARD-2585
Featured
ARD-2585 is an exceptionally potent and orally active PROTAC degrader of androgen receptor. |
2757422-79-8 |
DC47193 |
OICR-9429-N-C2-NH2
OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs. |
2407457-55-8 |
DC47204 |
Thalidomide-Piperazine-PEG1-NH2 diTFA
Thalidomide-Piperazine-PEG1-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
|
DC47206 |
Thalidomide-5-CH2-NH2 hydrochloride
Thalidomide-5-CH2-NH2 (hydrochloride) is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-CH2-NH2 (hydrochloride) can be connected to the ligand for protein by a linker to form PROTACs. |
1010100-22-7 |
DC47208 |
Pomalidomide-5-OH
Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTAC. |
1547162-41-3 |
DC47212 |
Boc-bipiperidine-ethynylbenzoic acid
Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61. |
2308497-81-4 |
DC47213 |
L-Homopropargylglycine hydrochloride
L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor. |
942518-19-6 |
DC47215 |
Thalidomide-4-C3-NH2 hydrochloride
Thalidomide-4-C3-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs. |
2357110-84-8 |
DC47216 |
Thalidomide-5,6-F
Featured
Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs. |
1496997-41-1 |
DC47217 |
Pomalidomide-7-NH2
Pomalidomide-7-NH2 is the Pomalidomide-based cereblon ligand used in the recruitment of CRBN protein. Pomalidomide-7-NH2 can be connected to the ligand for protein by a linker to form PROTACs. |
497146-96-0 |
DC47218 |
PROTAC CBP/P300 Degrader-1
PROTAC CBP/P300 Degrader-1 is a potent PROTAC CBP/P300 degrader. PROTAC CBP/P300 Degrader-1 potently inhibited cell viability of multiple cancer cell lines. |
2484739-48-0 |
DC47265 |
ARD-61
ARD-61 is a highly potent, effective and specific PROTAC androgen receptor (AR) degrader. ARD-61 potently and effectively induces AR and progesterone receptors (PR) degradation in AR+ cancer cell lines. ARD-61 induces apoptosis and effectively induces tumor growth inhibition in the MDA-MB-453 xenograft model in mice. |
2316837-08-6 |
DC47319 |
Dovitinib-RIBOTAC
Dovitinib RIBOTAC is a targeted RNA degrader that cleaves pre-miR-21 with enhanced potency and selectivity. |
|
DC47360 |
MS4322
MS4322 is a first-in-class PRMT5 degrader and a valuable chemical tool for exploring the PRMT5 functions in health and disease. |
2601727-80-2 |
DC47361 |
PZ703b
Featured
PZ703b is highly potent in killing BCL-XL dependent, BCL-2 dependent, and BCL-XL/BCL-2 dual-dependent cells in an E3 ligase (VHL)-dependent fashion. |
2471970-56-4 |
DC47362 |
MS21
MS21, a novel degrader of AKT, selectively inhibits the growth of PI3K/PTEN pathway-mutant cancers with wild-type KRAS and BRAF. |
2376137-05-0 |
DC47363 |
PROTAC CDK9 degrader-4
PROTAC CDK9 degrader-4 is a highly potent and efficacious CDK9 degrader for targeting transcription regulation. |
2411021-01-5 |
DC47364 |
ZXH-4-137
ZXH-4-137 is a potent and selective CRBN degrader (PROTAC). |
2711006-74-3 |
DC47365 |
di-Ellipticine-RIBOTAC
di-Ellipticine-RIBOTAC is a dual-function small molecule that reduces c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo amyotrophic lateral sclerosis (ALS ) models. |
|
DC47366 |
CFT-2718
CFT-2718 is a new BRD4-targeting degrader (PROTAC) with enhanced catalytic activity and in vivo properties. |