Cat. No. | Product name | CAS No. |
DC49184 |
t-Boc-N-amido-PEG15-Br
t-Boc-N-amido-PEG15-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
DC49195 |
m-PEG18-acid
m-PEG18-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
DC49196 |
Pomalidomide-C5-Dovitinib
Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia. |
2732969-67-2 |
DC49197 |
PROTAC BRD9 Degrader-2
PROTAC BRD9 Degrader-2 is a BRD9 bifunctional degrader for treating cancer. |
2633631-78-2 |
DC49207 |
ML 2-14
ML 2-14 is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. ML 2-14 can be used in the synthesis of the PROTAC. |
|
DC49209 |
HDAC6 degrader-1
HDAC6 degrader-1 is a PROTAC that comprises a selective HDAC6 inhibitor Nexturastat A (Nex A) as the HDAC6 binder, a linker and a ligand for recruiting E3 ligase. HDAC6 degrader-1 induces significant degradation of HDAC6, exhibits excellent selectivity against other HDACs, and demonstrates efficient inhibition of cell proliferation. |
2439058-23-6 |
DC49213 |
Mal-amido-PEG15-acid
Mal-amido-PEG15-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
DC49231 |
SJ10542
SJ10542 is a potent and selective JAK2/3 directing phenyl glutarimide (PG)-PROTAC with DC50s of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. SJ10542 utilizes a PG ligand as the cereblon (CRBN) recruiter. |
|
DC49232 |
PROTAC BRD9 Degrader-3
PROTAC BRD9 Degrader-3 is a BRD9 bifunctional degrader for treating cancer. |
2633632-05-8 |
DC49245 |
PROTAC BRD9 Degrader-4
PROTAC BRD9 Degrader-4 is a BRD9 bifunctional degrader for treating cancer. |
2633632-34-3 |
DC49252 |
PROTAC ER Degrader-10
PROTAC ER Degrader-10 is a potent PROTAC ER degrader and can be used for cancer research. PROTAC ER Degrader-10 is extracted from patent WO2021133886, example 36. |
2504911-58-2 |
DC49255 |
Biotin-Thalidomide
Biotin-Thalidomide is a cereblon affinity probe for PROTAC and targeted protein degradation research. |
2230857-87-9 |
DC49260 |
C18-PEG13-acid
C18-PEG13-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
DC49266 |
ZXH-4-130 TFA
ZXH-4-130 TFA is a highly potent and selective degrader of CRBN. ZXH-4-130 is a CRBN-VHL compound (hetero-PROTAC). |
2711006-67-4 |
DC49270 |
DBCO-N-bis(PEG4-NHS ester)
DBCO-N-bis(PEG4-NHS ester) is a PEG linker which contains two PEG4-NHS ester and a DBCO group. DBCO-N-bis(PEG4-NHS ester) is useful for protein modification or labeling. |
2639395-38-1 |
DC49309 |
PhosTAC7
Similar to PROTACs in their ability to induce ternary complexes, PhosTAC7 focuses on recruiting a Ser/Thr phosphatase to a phosphosubstrate to mediate its dephosphorylation. |
|
DC49320 |
Bromo-PEG2-acetic acid
Bromo-PEG2-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
2409962-85-0 |
DC49364 |
PROTAC Bcl-xL degrader-3
PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader (WO2020163823A2, compound 44). |
2471970-60-0 |
DC49373 |
Thiol-PEG3-acetic acid
Thiol-PEG3-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
200291-35-6 |
DC50135 |
PROTAC EGFR degrader 2
PROTAC EGFR degrader 2 is a potent PROTAC EGFR degrader. PROTAC EGFR degrader 2 exhibits excellent antiproliferative activity with IC50 of 4.0 nM and good EGFR degradation activity with DC50 of 36.51 nM. PROTAC EGFR degrader 2 can be used for the synthesis of nitroreductase (NTR)-responsive PROTAC. |
|
DC50136 |
PROTAC AR-V7 degrader-1
PROTAC AR-V7 degrader-1 (Compound 6) is a potent, orally bioavailable and selective AR-V7 degrader with the DC50 of 0.32 µM by recruiting VHL E3 ligase to Androgen receptor (AR) DNA binding domain (DBD) binder. PROTAC AR-V7 degrader-1 exhibits activity against 22Rv1 cell-line expressing AR-V7 with the EC50 of 0.88 µM. |
|
DC50137 |
MI-389
MI-389 is a PROTAC translation termination factor GSPT1 degrader. MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4CRBN E3 ligase. |
2222635-92-7 |