Cat. No. | Product name | CAS No. |
DC50138 |
PROTAC ERα Y537S degrader-1
PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Y537S degrader-1 extracts from patent WO2021143822, example 12. PROTAC ERα Y537S degrader-1 is an estrogen receptor-alpha (ERα) Y537S degrader. |
2667598-05-0 |
DC50139 |
PROTAC HSP90 degrader BP3
PROTAC HSP90 degrader BP3 is a potent and selective degradation of HSP90 in a CRBN-dependent fashion. PROTAC HSP90 degrader BP3 has a certain certain degradation effect on HSP90 protein in MCF-7 cells (DC50=0.99 µM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell. |
2669072-88-0 |
DC50141 |
SB1-G-187
SB1-G-187, a PROTAC, is a multi-kinase degrader. |
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DC50142 |
DB-0646
DB-0646, a PROTAC, is a multi-kinase degrader. |
|
DC50219 |
NJH-2-030
NJH-2-030 can be used as a covalent recruiter for FEM1B in targeted protein degradation applications. |
2709040-02-6 |
DC50245 |
(S)-CFT7455
(S)-CFT7455 is an orally active zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3) degrader. (S)-CFT7455 is an anti-cancer agent that binds with high affinity to the cereblon E3 ligase (Kd of 0.9 nM)(WO2022032132A1; Compound 1). |
2504235-67-8 |
DC50247 |
Cereblon inhibitor 1
Cereblon inhibitor 1, an isoindoline derivative, is a cereblon E3 ubiquitin ligase modulating drug. Cereblon inhibitor 1 has the potential for cancer research. |
2672489-14-2 |
DC50269 |
DBCO-PEG6-amine TFA
DBCO-PEG6-amine (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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DC50270 |
TCO-PEG2-Sulfo-NHS ester sodium
TCO-PEG2-Sulfo-NHS ester sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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DC50038 |
PROTAC SGK3 degrader-1
Featured
PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on PROTAC. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate). |
2381320-35-8 |
DC50053 |
E3 Ligase Ligand-Linker Conjugates 20
Featured
Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. |
1950635-15-0 |
DC50055 |
Thalidomide-NH-C6-NH2
Featured
Thalidomide-NH-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
2093386-50-4 |
DC50056 |
Thalidomide-PEG2-C2-NH2
Featured
Thalidomide-PEG2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. |
2093416-32-9 |
DC50057 |
E3 ligase Ligand-Linker Conjugates 30
Featured
E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrader[1]. |
2093416-31-8 |
DC50058 |
VH032-C3-NH2((S,R,S)-AHPC-C3-NH2)
Featured
(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852. UNC6852 is an EED-targeted bivalent chemical degrader[1]. |
2361119-88-0 |
DC50059 |
(S,R,S)-AHPC-C4-NH2
Featured
(S,R,S)-AHPC-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC[1]. |
2138439-53-7 |
DC50060 |
(S,R,S)-AHPC-C2-NH2 dihydrochloride
Featured
(S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs[1]. |
2341796-73-2 |
DC50061 |
Pomalidomide-C2-NH2(E3 ligase Ligand 17)
Featured
E3 ligase Ligand 17 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. |
1957235-66-3 |
DC50062 |
Thalidomide-NH-PEG1-C2-NH2
Featured
Thalidomide-NH-PEG1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
2138439-12-8 |
DC50063 |
(S,R,S)-AHPC-C6-NH2
Featured
PROTAC building block. |
2306389-03-5 |
DC50064 |
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2)
Featured
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC. |
2341796-74-3 |
DC50065 |
(S,R,S)-AHPC-CO-CI-Br
Featured
(S,R,S)-AHPC-CO-CI-Br is a novel protac building block, |
2379404-33-6 |