Benznidazol (Synonyms: Ro 07-1051; Ro 71051)

Cas No.:	22994-85-0
Chemical Name:	Benznidazol
Synonyms:	1H-Imidazole-1-acetamide,2-nitro-N-(phenylmethyl)-;Benznidazole;N-Benzyl-2-Nitro-1H-Imidazole-1-Acetamide;N-benzyl-2-(2-nitroimidazol-1-yl)acetamide;Radanil;Benzonidazole;Benznidazol;benzonidazol;Benznidazolum;N-Benzyl-2-nitroimidazole-1-acetamide;N-Benzyl-2-nitroimidazol-1-yl-acetamide;Rochagan;Benznidazolum [INN-Latin];Benznidazol [INN-Spanish];1H-Imidazole-1-acetamide, 2-nitro-N-(phenylmethyl)-;Ro 71051;N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide;2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide;Imidazole-1-acetamide, N-be;Ro 07-1051;N-Benzyl-2-nitro-1H-imidazole-1-acetamide;1H-Imidazole-1-acetamide, 2-nitro-N-(phenylmethyl)- [;CS-0013411;CCG-267054;BENZNIDAZOLE (MART.);AKOS024283499;Tox21_112364;N-benzyl-2-(2-nitro-1Himidazol-1-yl)acetamide;MLS001360496;CHEMBL110;J-014932;P01CA02;benznidazole (TN);HMS3369C11;BDBM50089916;Benznidazole [INN];BENZNIDAZOLE [USAN];BENZNIDAZOLE [ORANGE BOOK];NSC-299972;AS-68694;1H-Imidazole-1-acetamide,2-Nitro-n-(phenylmethyl)-;D02489;YC42NRJ1ZD;SR-01000841264;NSC 299972;NSC299972;Benznidazolum (INN-Latin);N-benzyl-2-nitro-1-imidazoleacetamide;SR-01000841264-3;C74184;CCRIS 2200;Rochagan (TN);RO-07-1051;Imidazole-1-acetamide, N-benzyl-2-nitro-;A912716;BENZNIDAZOLUM [WHO-IP LATIN];22994-85-0;BRD-K56156805-001-05-4;Acetamide, N-benzyl-2-(nitroimidazol-1-yl)-;SMR000857153;HMS2233G13;Pyridinium,1-dodecyl-2-[(hydroxyimino)methyl]-,iodide(1:1);NCGC00166238-01;DTXCID7026570;MLS001332409;EN300-1716737;HY-B1548;s3741;N-Benzyl-2-(2-nitro-imidazol-1-yl)-acetamide;CHEBI:133833;UNII-YC42NRJ1ZD;DB11989;Q425300;CAS-22994-85-0;Ragonil;MMV688773;MFCD00243089;Benznidazol (INN-Spanish);MLS001332410;BENZNIDAZOLE;AKOS015916722;SCHEMBL45081;BENZNIDAZOLE [MART.];Ro 07-1051;Ro 71051;SCHEMBL22493029;Tox21_112364_1;NS00068191;NCGC00166238-02;BENZNIDAZOLE [MI];N-Benzyl-2-(2-nitro-imidazol-1-yl)-acetamide (Benznidazole);SR-01000841264-4;BENZNIDAZOLE [WHO-IP];BENZNIDAZOLE [WHO-DD];Z2044771577;DTXSID9046570;Radanil (TN);Benznidazol (Ro 07-1051; Ro 71051);BRN 0551486;Ro-7-1051;N-benzyl-2-(2-nitro-1H-imidazol-5-yl)acetamide;N-Benzyl-2-nitro-1H-imidazole-1-acetamide, 97%;FT-0662547;Benznidazole (USAN/INN);Benznidazole [USAN:INN]
SMILES:	O=C(C([H])([H])N1C([H])=C([H])N=C1[N+](=O)[O-])N([H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H]
Formula:	C₁₂H₁₂N₄O₃
M.Wt:	260.2487
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

In Vivo Benznidazole (100 mg/kg/day, p.o., 30 days) produces a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac-receptors, and few isolated areas of fibrosis in the heart, in mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12 isolate and treated at 180 days post infection (p.i.) (i.e. chronic phase) with Benznidazole.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC33635	DODAP	DODAP, also known as 1,2-Dioleoyl-3-dimethylammonium-propane, is a cationic lipid. It has been used as a component in liposomes that can be used to encapsulate siRNA, immunostimulatory oligodeoxynucleotides, antisense oligonucleotides, or chemotherapeutic agents for in vitro and in vivo delivery.
DC31074	Isopropyl myristate	Isopropyl myristate is the ester of isopropyl alcohol and myristic acid.
DC74557	PREX-in1	PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic DH domain.
DC74555	GYS32661	GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays.
DC74539	L557-0155	L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth.
DC74528	K284	K284 is a selective small molecule inhibitor of chitinase 3 like1 (CHI3L1) with strong binding affinity (Kd=-9.7 kcal·mol-1), inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals.
DC74225	YB-537	YB-537 (YB537) is a potent, highly specific quinone reductase 2 (QR2) inhibitor with IC50 of 3 nM, shows no activity against QR1 (IC50>10 uM).
DC74218	UT-59	UT-59 is a specific inhibitor of cholesterol-sensing membrane protein Scap, binds to Scap's cholesterol-binding site, blocks SREBP activation and inhibits lipid synthesis.
DC74205	Tryptolinamide	Tryptolinamide (TLAM) is a small-molecule compound that activates mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs, inhibits phosphofructokinase-1 (PFK1) with an ATP-uncompetitive
DC74198	TMX-4102	TMX-4102 (TMX4102) is a highly potent, selective PIP4K2C binder with KD of 0.45 nM, shows no affinity for PIP4K2B and PIP4K2A (KD>10 uM).

Benznidazol (Ro 07-1051; Ro 71051)