DODAP
Cat. No.: DC33635
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Chemical Structure
127512-29-2
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Field of application
DODAP, also known as 1,2-Dioleoyl-3-dimethylammonium-propane, is a cationic lipid. It has been used as a component in liposomes that can be used to encapsulate siRNA, immunostimulatory oligodeoxynucleotides, antisense oligonucleotides, or chemotherapeutic agents for in vitro and in vivo delivery.
| Cas No.: |
127512-29-2 |
| Chemical Name: |
9Z-octadecenoic acid, 1,1'-[1-[(dimethylamino)methyl]-1,2-ethanediyl] ester |
| Synonyms: |
18:1 DAP; DODAP; 1,2-Dioleoyl-3-dimethylammonium-propane; |
| SMILES: |
CN(CC(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)C |
| Formula: |
C41H77NO4 |
| M.Wt: |
648.07 |
| Purity: |
>98% |
| Sotrage: |
-20°C |
| Description: |
DODAP is a cationic lipid. The ionizable lipid DODAP is a lipid component of the liposome. DODAP can be used to encapsulate siRNA, immunostimulatory chemotherapeutic agents for in vitro and in vivo delivery and so on[1][2][3]. |
| References: |
[1]. Dabbas S, et al. Importance of the liposomal cationic lipid content and type in tumor vascular targeting: physicochemical characterization and in vitro studies using human primary and transformed endothelial cells. Endothelium. 2008;15(4):189-201.
[2]. Hamzah J, et al. Targeted liposomal delivery of TLR9 ligands activates spontaneous antitumor immunity in an autochthonous cancer model. J Immunol. 2009;183(2):1091-1098.
[3]. Liu Q, et al. Biotinylated cyclen-contained cationic lipids as non-viral gene delivery vectors. Chem Biol Drug Des. 2013;82(4):376-383. |
MSDS
| TITLE |
DOWNLOAD |
| MSDS_15946_DC33635_127512-29-2 |
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