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BAMB-4(ITPKA-IN-C14)

  Cat. No.:  DC23979   Featured
Chemical Structure
891025-25-5
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More than 5000 active chemicals with high quality for research!
Field of application
A specific and membrane-permeable inhibitor of the InsP3Kinase activity of ITPKA (inositol-1,4,5-trisphosphate-3-kinase A) with IC50 of 20 uM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 891025-25-5
Chemical Name: Benzamide, N-1,2-benzisoxazol-3-yl-4-methyl-
Synonyms: ITPKA-IN-C14,BAMB-4,BAMB4,BAMB 4
SMILES: O=C(C1=CC=C(C)C=C1)NC2=NOC3=CC=CC=C23
Formula: C15H12N2O2
M.Wt: 252.268
Description: BAMB-4(ITPKA-IN-C14) is a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A((ITPKA) with IC50 of 37 uM in ADP-Glo Assay.BAMB-4 exhibit the lowest inhibition frequency among the InsP3-Kinase inhibitors. only in one from 42 targets tested,BAMB-4 showed an inhibitory effect. Noteworthy, in kinasescreens no targets of BAMB-4 were detected, indicating that thecompound does not belong to the typical kinase inhibitors. Thus,the relative high speci?city and the high cellular uptake ofBAMB-4 now for the ?rst provide the possibility to effectively inhibit InsP3kinase in vivo. e InsP3Kinase activity is essentially involved in ITPKA promoted metastasis of lung cancer cells, BAMB-4 is a promising therapeutic approach in lung cancertherapy.
Target: IC50 value: 37 uM Target: ITPKA inhibitor
References: [1]. Schroder D, et al. Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A. Biochem Biophys Res Commun. 2013 Sep 20;439(2):228-34.
MSDS
COA
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2018-0101
2018-0101
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