Cat. No.:  DC53045   Featured
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
STM2457 is in stock, and we can ship it immeidately. STM2457 is a potent inhibitor of METTL3/METTL14 catalytic activity with IC50 of 16.9 nM, Kd of 1.4 nM, respectively. STM2457 is highly specific for METTL3 and shows significant anti-leukaemic effect.
Cas No.: 2499663-01-1
Chemical Name: STM2457
Synonyms: STM2457;STM-2457;STM 2457
Formula: C25H28N6O2
M.Wt: 444.23
Purity: >99%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: Small molecule inhibition of METTL3 as a strategy against myeloid leukaemia--Nature-Eliza Yankova, Wesley Blackaby-Published: 26 April 2021
Cat. No. Product name Field of application
DC33635 DODAP DODAP, also known as 1,2-Dioleoyl-3-dimethylammonium-propane, is a cationic lipid. It has been used as a component in liposomes that can be used to encapsulate siRNA, immunostimulatory oligodeoxynucleotides, antisense oligonucleotides, or chemotherapeutic agents for in vitro and in vivo delivery.
DC58047 PEG2000-DSPE PEG2000-DSPE is used for creating micelles that are able to carry drugs with low solubility.
DC31000 LP-01 LP-01 is a cationic lipids useful in the delivery of biologically active agents to cells and tissues.
DC58066 m7G(5')ppp(5')(2'OMeA)pG m7G(5')ppp(5')(2'OMeA)pG is a co-transcription capping reagent for in vitro transcription of 5'capped mRNA to produce Cap 1 structure. Cap AG has been shown in the literature to provide a capping efficiency of up to 98%. m7G(5')ppp(5')(2'OMeA)pG requires an AG initiator. m7G(5')ppp(5')(2'OMeA)pG typically provides >90% capped material generating a naturally occurring Cap 1 structure.
DC80099 PF-06885249(PF249) PF-249(PF06885249) is a potent, selective AMPK β1-containing complexes activator; increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 296 nM, potently inhibits de novo lipogenesis (IC50=15 nM) in primary rat hepatocytes.
DC60335 Centanamycin Centanamycin alkylates the A-T-rich minor groove of the DNA and thereby blocks DNA replication. Centanamycin potently inhibits replication of human cytomegalovirus (HCMV), mouse CMV (MCMV), and herpes simplex virus-2 (HSV-2) in vitro. Centanamycin-attenuated whole virion MCMV elicits a robust serum neutralizing antibody response and protects the mice from live-virus challenge.
DC82050 Coelenterazine H Coelenterazine h is a derivative of Coelenterazine. Coelenterazine h is more sensitive to Ca2+ than is the native complex, thus providing a valuable tool for measuring small changes in Ca2+ concentrations.
DC60334 DRP-104 DRP-104 is a 6-Diazo-5-oxo-l-norleucine (DON) peptide prodrug. DRP-104 delivers a prodigious 11-fold greater exposure of DON to tumor versus GI tissues.
DC60333 BRD7586 BRD-7586(BRD 7586) is a cell-permeable small molecule inhibitor of SpCas9 with EC50 of 6.2  µM and 5.7  µM in the eGFP-disruption and HiBiT-knock-in assays, respectively. BRD7586 specifically engages SpCas9 but not Cas12a in cells and enhances SpCas9 specificity at multiple loci.
DC82032 Methoxy-X04 Methoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques.