Cat. No.:  DC53045   Featured
Chemical Structure
For research use only. We do not sell to patients.
We match the best price and quality on market.
We are official vendor of:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
More than 5000 active chemicals with high quality for research!
Field of application
STM2457 is in stock, and we can ship it immeidately. STM2457 is a potent inhibitor of METTL3/METTL14 catalytic activity with IC50 of 16.9 nM, Kd of 1.4 nM, respectively. STM2457 is highly specific for METTL3 and shows significant anti-leukaemic effect.
Cas No.: 2499663-01-1
Chemical Name: STM2457
Synonyms: STM2457;STM-2457;STM 2457
Formula: C25H28N6O2
M.Wt: 444.23
Purity: >99%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: Small molecule inhibition of METTL3 as a strategy against myeloid leukaemia--Nature-Eliza Yankova, Wesley Blackaby-Published: 26 April 2021
Cat. No. Product name Field of application
DC70000 Lysyllysyllysine Lysyllysyllysine is a cationic moietie that may be used in the construction of gene delivery vectors and DNA nanoparticles.
DC33635 DODAP DODAP, also known as 1,2-Dioleoyl-3-dimethylammonium-propane, is a cationic lipid. It has been used as a component in liposomes that can be used to encapsulate siRNA, immunostimulatory oligodeoxynucleotides, antisense oligonucleotides, or chemotherapeutic agents for in vitro and in vivo delivery.
DC58047 PEG2000-DSPE PEG2000-DSPE is used for creating micelles that are able to carry drugs with low solubility.
DC31000 LP-01 LP-01 is a cationic lipids useful in the delivery of biologically active agents to cells and tissues.
DC58066 m7G(5')ppp(5')(2'OMeA)pG m7G(5')ppp(5')(2'OMeA)pG is a co-transcription capping reagent for in vitro transcription of 5'capped mRNA to produce Cap 1 structure. Cap AG has been shown in the literature to provide a capping efficiency of up to 98%. m7G(5')ppp(5')(2'OMeA)pG requires an AG initiator. m7G(5')ppp(5')(2'OMeA)pG typically provides >90% capped material generating a naturally occurring Cap 1 structure.
DC58002 Cyclo(Gly-L-Pro) Cyclo(Gly-(L)-Pro) shows immunostimulatory properties. Cyclo(Gly-l-Pro) exhibits potent inhibition of TNF-α release with the IC50 values of 4.5 ug/mL, respectively, it also exhibits significant diminution of IL-1β and IL-6 mRNA-expression levels and NO production.
DC58001 BioE-1197 BioE-1197 is a novel Pask inhibitor.
DC58150 PHD-1-IN-1 PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe2+ ion and induces the formation of an “Arg367-out” pocket[1].
DC58312 GDC-6036 GDC-6036 is a novel oral KRAS G12C inhibitor.
DC58308 ML-339 ML 339 is a potent and selective hCXCR6 antagonist (IC50 = 140 nM); 100-fold less active at the murine CXCR6 receptor (IC50 = 18 μM). Exhibits selectivity over CXCR5, CXCR4, CCR6 and APJ receptors (IC50 >79 μM).