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Trovirdine（LY300046）

  Cat. No.:  DC9671   Featured
Chemical Structure
149488-17-5
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More than 5000 active chemicals with high quality for research!
Field of application
Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 149488-17-5
Synonyms: LY300046; LY-300046; LY 300046
SMILES: C1=CC=NC(=C1)CCNC(=S)NC2=NC=C(C=C2)Br
Formula: C13H13BrN4S
M.Wt: 337.24
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.Trovirdine is currently in phase I clinical trials for potential use in thetreatment of AIDS.
Target: IC50 value: 7 nM Target: HIV-1
References: [1]. Zhang, H. et al. Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethylthiazolyl thiourea derivatives trovirdine and MSC-127. [2]. Cantrell, A.S. et al. Phenethylthiazolylthiourea (PETT) compounds as a newclass of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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