(+)-corynoline

  Cat. No.:  DC23048   Featured
Chemical Structure
18797-79-0
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More than 5000 active chemicals with high quality for research!
Field of application
Corynoline is a reversible and noncompetitive inhibitor of acetylcholinesterase(AChE) with the IC50 value of 30.6 microM, which exhibits the potent anti-inflammatory and/or immunosuppressive activity, the potent inhibitory activity of corynoline for the I
Cas No.: 18797-79-0
SMILES: [H][C@]12N(C)CC3=C([C@@]1(C)[C@@H](O)CC4=C2C=C(OCO5)C5=C4)C=CC6=C3OCO6
Formula: C21H21NO5
M.Wt: 367.399
Purity: >98%,Standard References Grade
Sotrage: 4 Degree for 1 year, -20 degree for more than 2 years
Description: Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].
References: [1]. Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25(6):817-9. [2]. Liu B, et al. Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Inflammation. 2018 Oct;41(5):1640-1647.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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