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dTAG-7

  Cat. No.:  DC12570   Featured
Chemical Structure
2064175-32-0
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Field of application
FKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2064175-32-0
Chemical Name: (1R)-3-(3,4-dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Synonyms: FKBP12 PROTAC dTAG-7
SMILES: N(C(=O)[C@@H](C1=CC(OC)=C(OC)C(OC)=C1)CC)1CCCC[C@@H]1C(O[C@H](C1=CC=CC=C1OCC(=O)NCCCOCCOCCOCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CCC1=CC=C(OC)C(OC)=C1)=O
Formula: C63H79N5O19
M.Wt: 1210.341
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Target: FKBP12(F36V) BRD4 Cereblon
Kinase Assay: [1]. Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441.
References: FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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