RP-3500 (Camonsertib, ATR inhibitor) is a highly potent and selective inhibitor of ATR kinase with an IC50 of 1 nM.

ART0380 (ART-0380) is a potent, selective and ATP-competitive ATR kinase inhibitor, inhibits ATR-ATRIP complex enzyme activity with IC50 of 51.7 nM, and phospho-Chk1 IC50 of 22 nM in cell western assay.

AZ32 (ATM inhibitor AZ32) is a potent, selective, orally bioavailable, BBB-penetrating ATM inhibitor with IC50 of <6.2 nM, effectively blocks ATM auto-phosphorylation at S1981 with IC50 of 0.31 uM.