AZ32|AZ-32|ATM inhibitor|CAS 2288709-96-4|DC Chemicals

Cas No.:	2288709-96-4
Chemical Name:	N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide
Synonyms:	AZ32,AZ 32, AZ-32
SMILES:	O=C(NC)C(C=C1)=CC=C1C2=CN=C3C=NC(C4=CC=CC=C4)=CN32
Formula:	C₂₀H₁₆N₄O
M.Wt:	328.13
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AZ32 is an orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) that radiosensitizes intracranial gliomas in mice. AZ32 was highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC3132	VE-821	VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki and IC50 of 13 nM and 26 nM, respectively.
DC7448	KU-60019	KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM.
DC1067	KU-55933	KU-55933 is a potent and specific ATM inhibitor with IC50 and Ki of 13 nM and 2.2 nM, respectively.
DC10080	GJ103 (sodium salt)	GJ103 sodium salt is an active analog of the read-through compound GJ072.
DC4112	CP466722	CP-466722 is an potent and reversible ATM inhibitor.
DC10526	BAY-1895344 HCl(Elimusertib)	BAY-1895344 is a potent and selective ATM inhibitor. BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride.
DC8468	AZD-6738	AZD6738 is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM. Phase 1/2.
DC10891	AZ-32	AZ32 is an orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) that radiosensitizes intracranial gliomas in mice.
DC10906	AZ31	AZ31 is a novel ATM inhibitor.