Novel selective inhibitor of plasma kallikrein, blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE

Novel negative allosteric modulator of the ß2-adrenergic receptor (ß2AR), inhibiting cAMP production through the ß2AR, but not that mediated by other Gs-coupled receptors, also inhibiting ß-arrestin recruitment to the activated ß2AR

Potent ligand of the serotonin (5-HT) and dopamine (DA) transporters used in diagonisis of Parkinson's disease as SPECT imaging precursor

Phytoestrogen, possessing typical curare-like action

Natural antibiofilm agent and adjuvant on the antifungal therapy related to resistant infections caused by C. glabrata

Selective beta-1 adrenergic receptor antagonist with antihypertensive and anti-glaucoma activities and devoid of intrinsic sympathomimetic activity

Novel Dual BET-BRD7/9 Bromodomain Inhibitor, showing a strong antiproliferative effect on various cancer cell lines that could not be observed for BD family selective inhibitors

Novel BET inhibitor, selectively targeting BRD4-BD1 bromodomain

Novel HIF Prolyl Hydrolase Inhibitor, preventing colonic inflammation and fibrosis in murine models of inflammatory bowel disease

Novel probe for neurofibrillary tangles (tau fibrils)

Novel potent and selective inhibitor of kynurenine aminotransferase II

Novel, systemically active kynurenine aminotransferase 2 (KAT2) inhibitor, significantly decreased escape latency in the Morris water maze, indicating improved performance in spatial and contextual memorynovel

Potent inhibitor of centrosomal clustering in malignant cells

Novel Aldose_reductase_inhibitor>aldose reductase (ALR2) inhibitor

Novel dual inhibitor of norepinephrine transporter (NET) function and thyrointegrin αvβ3 receptor

The first small-molecule substrate identified with high selectivity for BGT1 over the three other GAT subtypes; M1 muscarinic agonist

Cell-permeable apoptosis inducer, specifically preventing BH3 domain-mediated interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family

Reactive dark quencher used in a variety of Fluorescence Resonance Energy Transfer (FRET) DNA detection probe.

Novel photoactivatable form of serotonin

Novel PROTAC (proteolysis-targeting chimera) as a PTK2 protein degerader

Novel fluorophore substrate of the protease Cathepsin C (CatC), being highly selective versus the related proteases CatB, CatF, CatH, CatK, CatL and CatS

Novel potent inhibitor of human chymase with >100 fold selectivity against Cathepsin G