Potent HNF4α antagonist

Novel USP28 inhibitor

Novel selective RORgamma inhibitor, selectively inhibiting Th17 differentiation and RORgamma signature gene expression

Novel heparanase inhibitor

Potent inhibitor of SHIP-2 catalytic activity; Novel inositol polyphosphate surrogate modulating Ca responses in rat hepatocytes

Potent peptide opioid receptor agonist, alleviating LPS-Induced activation in rat primary microglial cultures in opioid receptor-dependent and receptor-independent manners

Novel adjuvant to repurpose azithromycin for use against Pseudomonas aeruginosa, exhibiting a 1024-fold reduction in the minimum inhibitory concentration of azithromycin in vitro and displays activity in a Galleria mellonella model of infection

Novel anti-HIV active dimeric prodrug of 2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine monophosphate (d4TMP)

Class I antiarrhythmic agent with chronotropic, inotropic, dromotropic and coronary vasodilator effects, potently blocking sodium channel

Novel anti-HIV active dimeric prodrug of 2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine monophosphate (d4TMP)

Selective hAMCase Inhibitor

Novel inhibitor of angiogenesis by regulating STAT3 and VEGF in breast cancer cells

Novel and selective Wnt signaling inhibitor

Novel inhibitor of LPS-induced inflammation in macrophages, improving survival in sepsis

UV stabilizer

Potent activator of the Neh2-luc reporter

Novel Orally Efficacious Pan-HDAC Inhibitor

Inactivator of GSTP1>GST P1-1 through the covalent modification of two Cys47 residues per dimer and one Cys101

Novel potent antagonist of RORγt function, displaying an increased selectivity for RORγt over RORα and PPARγ compared to the purely orthosteric and allosteric non-PEG-linked parent compounds

Potent and selective dual inhibitor of MEK5 and ERK5

Potent inhibitor of recombinant human and mouse Transglutaminase enzyme activity, mainly TG2 and the close related enzyme TG1

Novel potent and selective covalent Pin1 inhibitor