Novel Bumped-Kinase Inhibitor (BKI) for Cryptosporidiosis Therapy

Novel Bumped-Kinase Inhibitor (BKI) for Cryptosporidiosis Therapy

Novel potent and selective bumped kinase inhibitor (BKI) CpCDPK1 IC 50 0.0025 µM

Novel potent and selective bumped kinase inhibitor (BKI) CpCDPK1 IC 50 0.005 µM

Novel inhibitor of survivin transcription through a signal transducer and activator of transcription 3 (Stat3)-dependent mechanism, inhibiting tissue expression of survivin and inducing apoptosis in C4-2 skeletal tumor

Novel effective inhibitor of survivin expression at both the mRNA and protein levels in vitro, significantly reducing survivin in bone metastatic C4-2 tumors

Novel inhibitor of the expression of anti-apoptotic protein survivin and membrane-bound efflux pump ATP binding cassette B 1 (ABCB1, p-glycoprotein), presumably via signal transducer and activator of transcription 3 (Stat3), inhibiting human prostate canc

Bradykinin antagonist, causing impressive growth inhibition of lung and prostate tumors, displaying superior in vivo inhibitory effects than convential chemotherapeutic drugs

Natural anti-coronavirus agent

Natural Potent 14-3-3 inhibitor

Potent 14-3-3 inhibitor

Novel ERK inhibitor, inducing breast cancer cell apoptosis via mitochondrial pathway but independent on Ras/Raf/MEK pathway

Inhibitor of calpain, cathepsin L and cathepsin B

Inhibitor of Marburg virus (MARV) growth at noncytotoxic concentrations

Original TXA2 modulator, inhibiting the action of thromboxane A2 and 8-iso-prostaglandin F2alpha

Dual thromboxane synthase inhibitor and thromboxane receptor antagonist

Novel potent EGFR inhibitor

Novel LRP5/6-sclerostin interaction inhibitor, recovering the downregulated activity of the Wnt/β-catenin signaling pathway by competitive binding to the LRP5/6-sclerostin complex

Novel inhibitor of RNA polymerase I, causing nucleolar stress and showing potent anticancer activity across many tumor types

Novel potent cyclin-dependent kinases (CDK) inhibitor, inducing a strong cell cycle alteration

Potent and selective inhibitor of Cdk5/p25, protecting large population of cells against non-A

Metabolite of BML277 which is a selective checkpoint kinase 2 inhibitor