Potent antimicrobial peptide against gram-positive and gram-negative bacteria and relatively high LPS-neutralization activity

Novel enteroviral replication inhibitor through a non-capsid binding mode with EC 50 values of 2.5, 2.2, and 3.7 μM against hRV B14, A21, and A71, respectively, targeting the replication stages in the virus

Novel KATP channel opener, exerting cardioprotective effects by opening SarcKATP channels in rat models of ischemia/reperfusion-induced heart injury

Novel irreversible inhibitor of KRAS(G12C)

Novel specific inhibitor of oncogenic KRAS4b signaling, stabilizing the KRAS4b-PDEδ complex and remarkably decreasing tumor size and triggered apoptosis of tumor cells

Novel stabilizer of the KRAS4b-PDEδ complex, decreasing the proliferation of colorectal cancer cells, and increasing apoptosis via decreased activation of oncogenic KRAS4b signaling

Novel potent multi-kinase inhibitor, targeting Ron, Flt3 and TrkA as well as c-Met

Selective novel inhibitor of c-Met receptor tyrosine kinase with anticancer activity.

Novel potent, non-toxic, blood-brain barrier crossing, α5-GABA A R preferring ligand, enhancing a chloride-anion efflux that induces mitochondrial membrane depolarization and in response, TP53 upregulation and p53, constitutively phosphorylated at S392, c

Potassium channel opener

Topo II inhibitor, exhibiting cytotoxic effects against tumour cells

Novel neutrophil elastase (NE) inhibitor, decreasing expression of TGF-ß Signal Related Genes

Highly potent and selective antagonist for the AMPA receptors, exhibiting good neuroprotective effects in vivo

Novel highly selective β3-adrenoceptor agonist being developed for the treatment of diabetes and obesity

Novel Potent and Selective VIPR2 Antagonist, Counteracting Cognitive Decline in a Mouse Model of Psychiatric Disorders

Novel inhibitor of the permeability transition pore (PTP)

Selective ligand of the sigma-1 receptor

Ligand of the sigma receptor

Ligand of the sigma receptor

Novel inhibitor of transcriptional activity in Chlamydia trachomatis

Novel, highly potent, and metabolically stable peptide inhibitor of syntenin, Inhibiting Glioblastoma

Novel modulator of kinesin spindle protein (KSP)/Eg5, activating KSP-catalyzed ATP hydrolysis in the absence of microtubules yet inhibiting microtubule-stimulated ATP hydrolysis by KSP