Selective Inhibitor of Human Lactate Dehydrogenase Isoform A (LDH-A)

Novel inhibitor of the sterol regulatory element binding protein (SREBP)

Antilipidemic agent

Novel fluorescent probe for imaging α4β2* nAChRs

Potent and selective NOP receptor antagonist

Cyclophilin inhibitor, showing reduction in interleukin-2 expression and reduction in CNS inflammatory infiltrates, inhibiting HCoV-229E replication

Novel potent tyrosine kinase inhibitor (TKI), targeting c-Met, VEGFR2 and Axl

Novel potent PARP1 inhibitor

Novel self-immobilizing near-infrared (NIR) fluorogenic probe that can be activated by senescence-associated ß-galactosidase (SA-ß-Gal), the most widely used senescence marker

Novel highly selective and sensitive near-infrared fluorescent probe for imaging of hydrogen sulphide in living cells and mice

Novel precursor of bright-emission NIR-II fluorophores for in vivo tumor imaging and image-guided surgery

NIR emitting firefly luciferin analogue, displaying dose-independent improved NIR emission even at low concentrations where the native d-luciferin substrate does not emit

Novel NIR NIR O2˙– probe, displays superior sensitivity to NIR O2˙– and having the capability to monitor trace amounts of intracellular NIR O2˙– in AKI in vivo

Antiviral agent against KFDV, AHFV, OHFV, as well as tick-borne encephalitis virus (TBEV) and mosquito-borne flaviviruses

Selective modulator of amyloid-beta peptide degradation, regulating Abeta levels

Novel pan-caspase inhibitor, potently reducing not only inflammasome-mediated interleukin-1β (IL-1β) secretion but also osteoclast differentiation in BMMs

Neuroprotective, protecting neurons from death following cerebral anoxia (interruption of oxygen supply to the brain).

Topoisomerase I inhibitor prodrug, slowly hydrolyzing and releasing irinotecan, increasing drug penetration into tumors and decreasing drug clearance

Novel Enterovirus 71 Inhibitor, binding to the hydrophobic pocket in VP1 to block viral infection, exhibiting excellent antiviral activity (with an EC50 of 5.056 nM and a 100% protection rate for mice at a dose of 20 mg/kg) and low toxicity

Novel NLRP3 inhibitor, reducing caspase-1 activation, oligomerization of ASC, and therefore, IL-1β processing, showing a significant anti-inflammatory effect and reduced mechanical hyperalgesia at 3 and 10 mg/kg (i.p.) in an in vivo mouse of gout

Novel Nm23-H1 activator, exerting cytotoxic effects on metastatic breast cancer cells by inducing mitochondrial dysfunction only under glucose starvation

Novel inhibitor of the Gli1 transcription, inducing apoptosis in cancer cells but not in non-cancerous cells