Proteolysis targeting chimeras (PROTAC), providing broad tissue distribution and knockdown of the targeted ERRalpha protein in tumor xenografts

Proteolysis targeting chimeras (PROTAC), providing broad tissue distribution and knockdown of the targeted RIPK2 protein in tumor xenografts

Novel SirReal-based PROTAC, inducing isotype-selective Sirt2 degradation, resulting in the hyperacetylation of the microtubule network coupled with enhanced process elongation

Novel selective and potent Fak degrader

The most potent and selective ERRα degrader

Novel PROTAC, targeting steroid hormone receptors for ubiquitination and degradation

Novel bacterial polyyne contributing to the antioomycete and plant-protective effects of P. protegens

Novel selective CB2 agonist (CB2: 17.4 nM and CB1: 5585 nM)

Novel potent and selective inhibitor of SETD2

Selective 5-HT4 agonist

Novel selective 5-HT6 receptor antagonist, enhancing cognition and memory and potently decreasing food intake and body weight in rodents

Novel potent and selective 5-HT2B receptor antagonist

Novel inhibitor of upstream IκB kinase (IKK), specifically inhibiting the IκB phosphorylation and degradation and the subsequent nuclear translocation of NF-κB

Highly potent and selective VDR-coactivator inhibitor

Naturally occurring inhibitor of FOXO1a nuclear export

Unique inhibitor of bacterial chromosomal partitioning, increasing the efficacy of bortezomib and sorafenib through regulation of stress granule formation

Potent competitive antagonist and positive modulator of the P2X2 receptor with >100-fold selectivity versus P2X4, P2X7, and several investigated P2Y receptor subtypes (P2Y(2,4,6,12))

Positive modulator of ATP effects at P2X2 receptors

Potent competitive antagonist and positive modulator of the P2X2 receptor

Novel fluorescent-labeled selective adenosine A2B receptor antagonist

Highly potent, selective, competitive, and reversible inhibitor of monoamine oxidase B (MAO-B)

Highly potent, selective, competitive, and reversible inhibitor of monoamine oxidase B (MAO-B)