The first potent inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt

Novel potent and selective RORγt agonist, showing robust antitumor efficacy in syngeneic tumor models and improving the efficacy of anti‑PD‑1 in a murine lung cancer model

Novel RORgammaT inhibitor

Novel RORγt agonist

Novel potent RORγt inverse agonist

Novel potent and selective CB2 probe (Ki for CB2: 0.8 nM and >12000 selectivity over CB1)

Novel P2X3 antagonist

Photosensitiser for the treatment of age-related macular degeneration

Novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor

Prodrug of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148

Specific and competitive H2 receptor antagonist

Potent agonist of S1P1 receptors

Novel non-peptidic RANTES antagonist

Novel stimulator of autophagy, inhibiting Mycobacterium tuberculosis survival in macrophages, and targeting Pik1

Novel stimulator of host immune defenses, Inducing the transcription of putative immune effectors in C. elegans

Novel inhibitor of β-amyloid-induced cytotoxicity

Selective collagenase inhibitor, inducing the conformational change in the side-chains of the S1 pocket of MMP-1

Potent and selective competitive antagonist of 5-HT4 receptors

Selective phosphodiesterase-4 (PDE4) inhibitor

Selective and reversible Monoamine_oxidase_A>monoamine oxidase A (MAO-A) inhibitor

Specific ligand to CB2-positive spleen tissue of rats and mice

Potent indirect activator of AMPK