Non-competitive modulator of the proteasome inducing apoptosis a panel of myeloma and leukemia cell lines

Novel TRPM8 channel blocker

Potent TRPM8 antagonist, exhibiting antiallodynic properties in pain models

Antimalarial; Novel inhibitor of HepG2

Novel Inhibitor of the malaria parasite protein kinase CLK3, inhibiting the development of liver-stage parasites, killing asexual blood-stage parasites at the trophozoite and schizont stages of the erythrocytic cycle, blocking the development of sexual ga

Highly potent NR2B-selective NMDA receptor antagonist

Nonpeptide partial agonist of oxytocin (OT) and vasopressin V2 receptors

Potent and selective polo-like kinase 2 (PLK2) inhibitor

Novel potent and selective CHK1 kinase inhibitor

Novel Integrin very late antigen-4 (VLA-4; α4β1) antagonist, blocking the activation of inflammatory cells.

Novel GPR35 agonist

Insulin receptor sensitizing agent; Selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B)

Potent equilibrative nucleoside transporter 4 (ENT4) inhibitor

Sorafenib analogue, retaining cytotoxicity similar to sorafenib in various human cancer cell lines and strongly inhibiting growth in the NCI-60 cell line panel

Novel degrader of the anaplastic lymphoma kinase (ALK) fusion protein, effectively inducing ALK degradation and inhibiting the growth of ALK fusion positive cell lines, SU-DHL-1 and H3122, significantly reducing the tumor growth in H3122 xenograft model

Novel IKZF1/3 degrader, inhibiting the proliferation of multiple myeloma cells in vitro as well as in vivo

Novel selective opioid receptor antagonist at all three receptor types

Novel potent BET protein degrader, inhibiting cell proliferation due to suppressed C-MYC transcription

Novel long-acting β 2 -adrenoceptor agonist

Hepatotoxicity inducer, significantly up-regulating the expression of genes involved in endoplasmic reticulum stress and Toll-like receptor (TLR) pathway

Novel Specific Copper Chelator, Reducing Memory Impairments in Alzheimer's Disease Mouse Models

Novel potent inhibitor of tyrosyl-DNA phosphodiesterase 1 (Tdp1)