Novel inhibitor of the p53-Hdm2 protein-protein interaction, dose-dependently stabilized P53 and increased P21 and MDM2 expression in JAR choriocarcinoma cells, inducing the p53 regulated gene (PIG-3) and caspase activity

Novel antimalarial agent

Novel inhibitor of viral p37, blocking the ability of virus particles to be released from infected cells, being used for the treatment of smallpox, monkeypox, orthopoxvirus, and orthopoxviral Disease.

Novel monocyte/macrophage targeted histone deacetylase inhibitor

CCR2b receptor antagonist

Natural antibacterial agent, being active against gram-positive bacteria.

Potent and selective M1 antimuscarinic

Mucolitic agent, inhibiting activation of nuclear factor kappa-κB (NF-κB) by blocking phosphoinositide 3-kinase/protein kinase B (PI3K/Akt)/IκB kinase (IKK) activities, showing the anti-inflammatory properties on inflammation-associated skin diseases

Photosensitizing agent used in the treatment of squamous cell carcinoma of the head and neck, also showing activity agaimst COVID-19 Mpro

COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory agent

Peptide vaccine, residues (611-626) of the human telomerase reverse transcriptase catalytic subunit (hTERT), for the treatment of solid cancers

Selective Thromboxane_receptor>thromboxane receptor antagonist

Mutually Orthogonal Bioorthogonal Amino Acid, Enabling Efficient Protein Dual-Labeling in Cells

Reversible inhibitor of vesicular monoamine transporter 2, showing anti-chorea effect and decreasing uptake of monamines into synaptic vesicles, as well as depletion of monoamine storage

Activator of the hepatic interferon pathway in rats

Potent inhibitor of protein synthesis, inhibiting translation by binding within the ribosomal exit tunnel

Inducer of S phase arrest and apoptosis in hepatocellular carcinoma QGY-7701

Antitubercular agent

Potent and selective human leukocyte 5-lipoxygenase (5-LOX) inhibitor

Novel endothelin (ET) receptor antagonist

Novel multipotent anti-Alzheimer agent, selectively inhibiting human butyrylcholinesterase (BChE), having strong antioxidant activity and good β-amyloid (Aβ) anti-aggregation properties

Novel GSK-3β inhibitor, showing anti-neuroinflammatory effects in lipopolysaccharide (LPS) activation of spontaneously immortalized SIM-A9 microglial cells and of mouse cortical microglia, inhibiting LPS-induced production of nitric oxide and the proinfla