Novel cell-active, selective class IIa HDAC inhibitor

CNS-penetrant selective class IIa histone deacetylase (HDAC) inhibitor, exploiting the >100-fold selectivity over class I/IIb HDACs

Cyclized tamoxifen analog, selective ER modulator (SERM)

Novel and Potent Stem Cell Mobilizer; Inhibitor of SDF-1α/CXCR4 binding

Novel potent SARS coronavirus (CoV) 3CL protease inhibitor (Ki = 53 nM)

Novel dual VEGFR/Src kinase inhibitor

Novel inhibitor of T315I mutant enzyme, exhibiting reasonable in vivo efficacy in a xenograft mouse model harboring T315I

Novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist

Novel inhibitor of mitochondrial calcium uptake (#333333; font-family: "Open Sans", HelveticaNeue, "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 15px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight:

Highly selective, potent, cell-permeable fluorescent irreversible tissue transglutaminase (TG2) inhibitor

EP2 allosteric potentiator

Potent and selective nociceptin opioid receptor (NOP) agonist

Potent and selective nociceptin opioid receptor (NOP) agonist

Potent and selective nociceptin opioid receptor (NOP) agonist

Potent and Selective Antagonist for Human EP2 Receptors

Novel potent and structure-specific inhibitor of pre-miR-200c, reversing a type 2 diabetes phenotype

Novel potent TGR5 agonist, displayind a significant glucose-lowering effect and stimulated GLP-1 and insulin secretion in TGR5H88Y mice but not in wild-type animals

Novel Potent Agonist of TGR5 Receptor

Cell-permeable, potent, and selective inhibitor of PI 3-K isoforms p110ß/p110d

Potent and selective inhibitor of PI 3-K

Novel highly potent and specific inhibitor of TLR8, targeting an unconventional pocket on the TLR8 protein-protein Interface

Natural potent human carboxylesterase 2 (hCES2) inhibitor (IC50: 5.05 μM)