Novel selective thrombin inhibitor, inducing conformational allostery

Novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor

Anti-epileptic and anticonvulsant agent, acting as a selective GABA reuptake inhibitor

Anthraquinone-fused enediyne antitumor agent for development of antibody-drug conjugates (ADCs)

Muscarinic receptor antagonist, anticholinergic,and parasympatholytic

Natural anticancer agent fortreatment of mast cell tumor (MCT)

Widely used oxidation-reduction indicator

Macrolide antibiotic for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia (Pasteurella) haemolytica

Antiviral, antineoplastic, and anti-inflammatory agent; Orally active interferon inducer, inhibiting Ebola virus (EBOV)

Novel pan-histone-deacetylase inhibitor with alkylating activity

Neurotoxin, acting via vanilloid receptors of sensory nerves

Novel hepcidin antagonist

hPPAR

Dual PPA

hPPAR-pan agonist

Anti-arrhythmia agent

Novel AC220-based FLT3 degrader

Novel AC220-based FLT3 degrader

The first small molecule degrader, inducing anaplastic lymphoma kinase (ALK) degradation, including in non-small-cell lung cancer (NSCLC), anaplastic large-cell lymphoma (ALCL), and neuroblastoma (NB) cell lines

The first small molecule degrader, inducing anaplastic lymphoma kinase (ALK) degradation, including in non-small-cell lung cancer (NSCLC), anaplastic large-cell lymphoma (ALCL), and neuroblastoma (NB) cell lines

Novel Insulin Receptor Modulator

Novel Toll-Like Receptor 4 (TLR4) Inhibitor